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Therefore, the aim of the present study was to investigate the effect of c\u2010tPCS at 4 and 75\u00a0Hz frequencies on corticospinal excitability (CSE) and motor performance. In a randomized sham\u2010controlled crossover design, fifteen healthy participants attended three experimental sessions and received either c\u2010tPCS at 75\u00a0Hz, 4\u00a0Hz or sham with 1.5\u00a0mA for 15\u00a0min. Transcranial magnetic stimulation and grooved pegboard test were performed before, immediately after and 30\u00a0min after the completion of stimulation at rest. The findings indicate that c\u2010tPCS at both 4 and 75\u00a0Hz significantly increased CSE compared to sham. Both c\u2010tPCS at 75 and 4\u00a0Hz showed a significant increase in intracortical facilitation compared to sham, whereas the effect on short\u2010interval intracortical inhibition was not significant. The c\u2010tPCS at 4\u00a0Hz but not 75\u00a0Hz induced modulation of intracortical facilitation correlated with the CSE. Motor performance did not show any significant changes. These results suggest that, compared with sham stimulation, c\u2010tPCS at both 4 and 75\u00a0Hz induces an increase in CSE.<\/jats:p>","DOI":"10.1111\/ejn.14916","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T03:19:41Z","timestamp":1595301581000},"page":"4908-4922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effects of a single\u2010session cathodal transcranial pulsed current stimulation on corticospinal excitability: A randomized sham\u2010controlled double\u2010blinded study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-7438","authenticated-orcid":false,"given":"Thusharika","family":"Dissanayaka","sequence":"first","affiliation":[{"name":"Non\u2010invasive Brain Stimulation &amp; Neuroplasticity Laboratory Department of Physiotherapy School of Primary and Allied Health Care Faculty of Medicine, Nursing and Health Sciences Monash University Melbourne Vic. 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