{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T11:24:38Z","timestamp":1781954678038,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["2015\u2010WSN\u2010050"],"award-info":[{"award-number":["2015\u2010WSN\u2010050"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701433"],"award-info":[{"award-number":["81701433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871154"],"award-info":[{"award-number":["81871154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) is characterized by chronic pain in pelvic area and lower urinary tract symptoms (LUTS). Previous neuroimaging studies demonstrated that chronic pain was associated with the altered brain activity. However, the pathological mechanisms associated with altered brain control of CP\/CPPS are not well\u2010understood. Therefore, we sought to investigate the topological properties of white matter brain networks in patients with CP\/CPPS and whether the topological configuration of frontal\u2010parietal control network was disrupted. We collected 19 patients with CP\/CPPS and 32 matched healthy controls (HCs). Diffusion tensor imaging data of all participates were used to map the white matter structural networks. Graph theoretical method was applied to investigate the alterations of topological properties of brain network in patients. Moreover, we also investigated whether the alerted brain regions might be correlated with any clinical features of patients by the method of\n                    <jats:italic>Pearson<\/jats:italic>\n                    correlation analysis. Both CP\/CPPS patients and HCs exhibited a \u2018small\u2010world\u2019 behavior or economical small\u2010world architecture of the white matter brain networks. In addition, CP\/CPPS had a lower global efficiency in the right middle frontal gyrus (orbital part) and a higher global efficiency in the left middle cingulate and paracingulate gyri. CP\/CPPS also showed increased local efficiency in the left middle cingulate and paracingulate gyri and paracentral lobule. Moreover, the local efficiency of the left middle cingulate gyrus was positively correlated with the scores of the influence of symptoms on the quality of life. The local efficiency of the left precuneus and right supplementary motor area were positively correlated with the total scores of NIH\u2010CPSI and the scores of pain and discomfort symptoms, respectively. Together, we found that patients with CP\/CPPS had alterations of connections within the frontal\u2010parietal control network, which suggested that the altered connectivity involved in the executive control processing procedures might contribute to the pathogenesis of the pelvic pain and LUTS in CP\/CPPS. Thus these results provided new insights into the understanding of CP\/CPPS.\n                  <\/jats:p>","DOI":"10.1111\/ejn.14962","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T17:58:27Z","timestamp":1601315907000},"page":"1060-1071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impaired frontal\u2010parietal control network in chronic prostatitis\/chronic pelvic pain syndrome revealed by graph theoretical analysis: A DTI study"],"prefix":"10.1111","volume":"53","author":[{"given":"Xinfei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 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