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This study investigated whether inter\u2010individual variability to tDCS was in\u2010part genetically mediated. In 61 healthy males, anodal\u2010tDCS (a\u2010tDCS) and sham\u2010tDCS were administered to the primary motor cortex at 1\u00a0mA for 10\u2010min via 6\u00a0\u00d7\u00a04\u00a0cm active and 7\u00a0\u00d7\u00a05\u00a0cm return electrodes. Twenty\u2010five single\u2010pulse transcranial magnetic stimulation (TMS) motor evoked potentials (MEP) were recorded to represent corticospinal excitability (CSE). Twenty\u2010five paired\u2010pulse MEPs were recorded with 3\u00a0ms inter\u2010stimulus interval (ISI) to assess intracortical inhibition (ICI) via short\u2010interval intracranial inhibition (SICI) and 10\u00a0ms ISI for intracortical facilitation (ICF). Saliva samples were tested for specific genetic polymorphisms in genes encoding for excitatory and inhibitory neuroreceptors. 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