{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:08:05Z","timestamp":1790669285336,"version":"4.1.0"},"reference-count":94,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["5K01AG049991"],"award-info":[{"award-number":["5K01AG049991"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG049813"],"award-info":[{"award-number":["K01AG049813"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG036921"],"award-info":[{"award-number":["R01AG036921"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG044007"],"award-info":[{"award-number":["R01AG044007"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["NICHD U54 HD090260"],"award-info":[{"award-number":["NICHD U54 HD090260"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007319","name":"Albert Einstein College of Medicine, Yeshiva University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006535","name":"CoreQuest Sagl","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006535","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Behavioral findings suggest that aging alters the involvement of cortical sensorimotor mechanisms in postural control. However, corresponding accounts of the underlying neural mechanisms remain sparse, especially the extent to which these mechanisms are affected during more demanding tasks. Here, we set out to elucidate cortical correlates of altered postural stability in younger and older adults. 3D body motion tracking and high\u2010density electroencephalography (EEG) were measured while 14 young adults (mean age\u00a0=\u00a024\u00a0years, 43% women) and 14 older adults (mean age\u00a0=\u00a077\u00a0years, 50% women) performed a continuous balance task under four different conditions. Manipulations were applied to the base of support (either regular or tandem (heel\u2010to\u2010toe) stance) and visual input (either static visual field or dynamic optic flow). Standing in tandem, the more challenging position, resulted in increased sway for both age groups, but for the older adults, only this effect was exacerbated when combined with optic flow compared to the static visual display. These changes in stability were accompanied by neuro\u2010oscillatory modulations localized to midfrontal and parietal regions. A cluster of electro\u2010cortical sources localized to the supplementary motor area showed a large increase in theta spectral power (4\u20137\u00a0Hz) during tandem stance, and this modulation was much more pronounced for the younger group. Additionally, the older group displayed widespread mu (8\u201312\u00a0Hz) and beta (13\u201330\u00a0Hz) suppression as balance tasks placed more demands on postural control, especially during tandem stance. These findings may have substantial utility in identifying early cortical correlates of balance impairments in otherwise healthy older adults.<\/jats:p>","DOI":"10.1111\/ejn.15004","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T22:32:01Z","timestamp":1602541921000},"page":"8139-8157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Aging\u2010related changes in cortical mechanisms supporting postural control during base of support and optic flow manipulations"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8035-8333","authenticated-orcid":false,"given":"Brenda R.","family":"Malcolm","sequence":"first","affiliation":[{"name":"The Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center (CERC) Department of Pediatrics Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Foxe","sequence":"additional","affiliation":[{"name":"The Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center (CERC) Department of Pediatrics Albert Einstein College of Medicine  Bronx NY USA"},{"name":"The Dominick P. Purpura Department of Neuroscience Rose F. Kennedy Intellectual and Developmental Disabilities Research Center Albert Einstein College of Medicine  Bronx NY USA"},{"name":"The Cognitive Neurophysiology Laboratory The Del Monte Institute for Neuroscience Department of Neuroscience University of Rochester School of Medicine and Dentistry  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Joshi","sequence":"additional","affiliation":[{"name":"The Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center (CERC) Department of Pediatrics Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Verghese","sequence":"additional","affiliation":[{"name":"The Saul R. Korey Department of Neurology Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette R.","family":"Mahoney","sequence":"additional","affiliation":[{"name":"The Saul R. Korey Department of Neurology Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Molholm","sequence":"additional","affiliation":[{"name":"The Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center (CERC) Department of Pediatrics Albert Einstein College of Medicine  Bronx NY USA"},{"name":"The Dominick P. Purpura Department of Neuroscience Rose F. Kennedy Intellectual and Developmental Disabilities Research Center Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierfilippo","family":"De Sanctis","sequence":"additional","affiliation":[{"name":"The Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center (CERC) Department of Pediatrics Albert Einstein College of Medicine  Bronx NY USA"},{"name":"The Saul R. Korey Department of Neurology Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00878-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(02)02021-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.12.1.12"},{"key":"e_1_2_10_5_1","unstructured":"Bates D. M\u00e4chler M. Bolker B. M. &Walker S. C.(2014).\"Ime4: Linear mixed\u2010effects models using Eigen and S4 (R package Version 1.1\u20107).\"from https:\/\/CRAN.Rproject.org\/package=lme4."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.06.021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.08.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00247"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1163\/187847511X588070"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.17.1.85"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2010.06.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00080"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.12.2301"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.12.2271"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019824"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00080"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20839"},{"key":"e_1_2_10_18_1","volume-title":"Delis\u2010Kaplan Executive Function System","author":"Delis D. C.","year":"2001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030135"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2017.03.018"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(99)00195-9"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.5.725"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172958.95282.2a"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.08.012"},{"key":"e_1_2_10_26_1","article-title":"Heading computation in the human retrosplenial complex during full\u2010body rotation","author":"Gramann K.","year":"2018","journal-title":"biorXiv"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NAJ.0000292204.52313.f3"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.066"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235816"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00242910"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2008.05.004"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1986.55.6.1369"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(89)90010-9"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.02.049"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-007-0657-0"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.08.002"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.05.017"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2004.09.008"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-2000-104-505"},{"key":"e_1_2_10_40_1","unstructured":"Kothe C.(2019). \"Artifact Subspace Reconstruction (ASR).\" 2019 from https:\/\/sccn.ucsd.edu\/wiki\/Artifact_Subspace_Reconstruction_(ASR)."},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4943(03)00082-7"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/03610739608254006"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(99)01364-9"},{"key":"e_1_2_10_45_1","first-page":"87","article-title":"Visual proprioceptive control of stance","volume":"1","author":"Lee D. N.","year":"1975","journal-title":"Journal of Human Movement Studies"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb05230.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1519\/00139143-200312000-00003"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly245"},{"key":"e_1_2_10_49_1","first-page":"145","article-title":"Independent component analysis of electroencephalographic data","volume":"8","author":"Makeig S.","year":"1996","journal-title":"Advances in Neural Information Processing Systems"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(18)30193-9"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-007-0764-y"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00079.2018"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28143"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(94)90137-6"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-017-0567-x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.07.029"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3886-06.2007"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913697107"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2015.2481482"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00607.2010"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235249"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2008.01.010"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10061"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2017.12.004"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405148101"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-1990-1108"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0207-18.2018"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089820"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.05.026"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2006.03.003"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005624"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.06.047"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00485"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.10.005"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.00036"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00744.2012"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.09.007"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00639"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.12.045"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1518\/001872000779698097"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2018.04.011"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/51A.2.M45"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-013-3756-1"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.12968\/ijtr.2013.20.6.280"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.01.055"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.08.019"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00093"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/336162a0"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.14.3.409"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAU.1967.1161901"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/0966-6362(96)82849-9"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.11.2069"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.2190\/VXN3-N3RT-54JB-X16X"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.15004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T10:43:28Z","timestamp":1693219408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.15004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":94,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/ejn.15004"],"URL":"https:\/\/doi.org\/10.1111\/ejn.15004","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.15004\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15004\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15004\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15004\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15004\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15004\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15004\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"assertion":[{"value":"2020-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}