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Although Parkinson's disease (PD) is primarily known as a movement disorder, recent research has redefined it as a multisystem disorder affecting cognition, in particular inhibitory control and attentional resource allocation. Analysing the neural mechanisms underlying this cognitive deficit provides a better understanding of brain changes observed in patients affected by PD. Therefore, this study aimed to identify resource allocation to relevant and irrelevant stimuli in patients affected by PD. Besides neuropsychological tests, we employed electroencephalographic recordings during an auditory oddball paradigm in 13 patients suffering from idiopathic PD and 11 healthy controls (HC). Participants were instructed to ignore the standard stimulus and to respond as fast as possible to the rarely presented target tone. Event\u2010related potentials (ERP) and time\u2010frequency representations (TFR) were analyzed. Patients affected by PD showed faster response latencies to the task\u2010irrelevant standard tones, but slower response latencies to target tones compared to HC. This observation was prominent at frontal sites during later P3\u2010like processing stages. Reaction time, however, was prolonged in patients with PD, suggesting inefficient resource allocation. Additionally, TFR revealed reduced parietal alpha activity, which is associated with distractor suppression and functional inhibition in patients with PD compared to healthy controls. Thus, our results point towards inefficient resource allocation in patients with PD possibly driven by less functional inhibition through parietal alpha activity.<\/jats:p>","DOI":"10.1111\/ejn.15008","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T20:21:14Z","timestamp":1602706874000},"page":"1225-1237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Inefficient resource allocation is associated with reduced alpha activity in parietal regions in individuals with Parkinson\u2019s disease"],"prefix":"10.1111","volume":"53","author":[{"given":"Jan","family":"Weber","sequence":"first","affiliation":[{"name":"Institute of Movement and Neurosciences German Sport University Cologne Germany"},{"name":"Graduate Training Center of Neuroscience University of Tuebingen Tuebingen Germany"},{"name":"Hertie\u2010Institute for Clinical Brain Research University Medical Center Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Abeln","sequence":"additional","affiliation":[{"name":"Institute of Movement and Neurosciences German Sport University Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Steichele","sequence":"additional","affiliation":[{"name":"Institute of Movement and Neurosciences German Sport University Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Foitschik","sequence":"additional","affiliation":[{"name":"Institute of Movement and Neurosciences German Sport University Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-4377","authenticated-orcid":false,"given":"Tim","family":"Stuckenschneider","sequence":"additional","affiliation":[{"name":"Institute of Movement and Neurosciences German Sport University Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.27"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.01.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.06.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.03.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617713000295"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnp.0000218991.99714.ee"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2009.02.023"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2008.03.011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.11.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnp.12028"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007725"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.11.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2007.00602.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2011.00154"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.03.017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-140398"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actpsy.2015.02.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20213"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.02.039"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117190108"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705965114"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.01.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-013-0327-5"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445751"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.10.019"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.04.010"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12671-020-01364-z"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2010.00186"},{"key":"e_1_2_9_33_1","first-page":"3","article-title":"The ten\u2010twenty electrode system of the International Federation. 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