{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:43:25Z","timestamp":1772160205354,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003354","name":"Garnett Passe and Rodney Williams Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1125376"],"award-info":[{"award-number":["1125376"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inactivating mutations of\n                    <jats:italic>SERPINB6<\/jats:italic>\n                    in humans result in progressive hearing loss starting in early adulthood (DFNB91). We have previously shown that C57BL\/6J mice lacking the orthologous gene,\n                    <jats:italic>Serpinb6a<\/jats:italic>\n                    , exhibit progressive hearing loss, which is associated with progressive loss of distinct cell types in the organ of Corti beginning with outer hair cells (OHCs). However, deafness in these animals occurs much earlier than expected, possibly because C57BL\/6J mice also carry an age\u2010related hearing loss mutation in the cadherin 23 gene (\n                    <jats:italic>\n                      Cdh23\n                      <jats:sup>ahl<\/jats:sup>\n                    <\/jats:italic>\n                    ) that causes late onset hearing loss. The CBA\/CaH strain of mice does not carry\n                    <jats:italic>\n                      Cdh23\n                      <jats:sup>ah\/ahl<\/jats:sup>\n                    <\/jats:italic>\n                    and may represent a better model of the human DFNB91 patients. Here, we show that transfer of the mutant\n                    <jats:italic>Serpinb6a<\/jats:italic>\n                    allele onto the\n                    <jats:italic>Cdh23<\/jats:italic>\n                    normal CBA\/CaH background markedly delays onset of hearing loss, more closely phenocopying DFNB91, without altering the pattern of cellular loss. Young, pre\u2010symptomatic mice of this genotype exposed to acoustic trauma exhibit permanent hearing loss, compared to controls, associated with the disappearance of OHCs. We conclude that Serpinb6 helps to maintain hearing by protecting hair cells from stress.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15011","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T09:27:34Z","timestamp":1603099654000},"page":"1638-1651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased susceptibility to acoustic trauma in a mouse model of non\u2010syndromic sensorineural deafness, DFNB91"],"prefix":"10.1111","volume":"53","author":[{"given":"Justin","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Melbourne East Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2692-030X","authenticated-orcid":false,"given":"Dion","family":"Kaiserman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology Monash University Clayton Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"O'Leary","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Melbourne East Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip I.","family":"Bird","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology Monash University Clayton Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162\u2010014\u20100491\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-69185-3_4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001073"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.04.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200214211"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.01.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101620010075"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.2.805"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.02.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20105955(97)00155\u2010X"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.213"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1226"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.11.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20105955(00)00191\u2010X"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.11.008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9425"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10210"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.04.004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908786106"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20105955(96)00106\u20102"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.418315"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.04.013"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.03.009"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101620020028"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162\u2010012\u20100329\u20100"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.112888"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.10.063"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00018.2009"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.26.15469"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20105955(99)00003\u20109"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.15011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T22:30:49Z","timestamp":1693089049000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.15011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,7]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/ejn.15011"],"URL":"https:\/\/doi.org\/10.1111\/ejn.15011","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.15011\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15011\/v2\/review2","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,7]]},"assertion":[{"value":"2020-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}