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Cannabidiol (CBD) is the main non\u2010psychotropic component found in cannabis that is capable of modulating mesocorticolimbic DA transmission and may possess therapeutic potential for several neuropsychiatric disorders. Emerging evidence also suggests that, similar to CBD, omega\u20103 polyunsaturated fatty acids may regulate DA transmission and possess therapeutic potential for similar neuropsychiatric disorders. Although progress has been made to elucidate the mechanisms underlying the therapeutic properties of CBD and omega\u20103s, it remains unclear through which receptor mechanisms they may produce their purported effects. Peroxisome proliferator\u2010activated receptors are a group of nuclear transcription factors with multiple isoforms. PPAR\u03b3 is an isoform activated by both CBD and omega\u20103, whereas the PPAR\u03b1 isoform is activated by omega\u20103. Interestingly, the activation of PPAR\u03b3 and PPAR\u03b1 with selective agonists has been shown to decrease mesocorticolimbic DA activity and block neuropsychiatric symptoms similar to CBD and omega\u20103s, raising the possibility that CBD and omega\u20103s produce their effects through PPAR signaling. This review will examine the relationship between CBD, omega\u20103s, and PPARs and how they may be implicated in the modulation of mesocorticolimbic DAergic abnormalities and associated neuropsychiatric symptoms.<\/jats:p>","DOI":"10.1111\/ejn.15023","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T18:44:36Z","timestamp":1603824276000},"page":"1088-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Functional interactions between cannabinoids, omega\u20103 fatty acids, and peroxisome proliferator\u2010activated receptors: Implications for mental health pharmacotherapies"],"prefix":"10.1111","volume":"55","author":[{"given":"Tony","family":"Jung","sequence":"first","affiliation":[{"name":"Addiction Research Group Schulich School of Medicine &amp; Dentistry University of Western Ontario  London ON Canada"},{"name":"Department of Anatomy &amp; Cell Biology Schulich School of 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