{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:33:58Z","timestamp":1789450438079,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Migraine patients often report (inter)ictal hypersensitivity to light, but the underlying mechanisms remain an enigma. Both hypo\u2010 and hyperresponsivity of the visual network have been reported, which may reflect either intra\u2010individual dynamics of the network or large inter\u2010individual variation in the measurement of human visual evoked potential data. Therefore, we studied visual system responsivity in freely behaving mice using combined epidural electroencephalography and intracortical multi\u2010unit activity to reduce variation in recordings and gain insight into visual cortex dynamics. For better clinical translation, we investigated transgenic mice that carry the human pathogenic R192Q missense mutation in the \u03b1\n                    <jats:sub>1A<\/jats:sub>\n                    subunit of voltage\u2010gated Ca\n                    <jats:sub>V<\/jats:sub>\n                    2.1 Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels leading to enhanced neurotransmission and familial hemiplegic migraine type 1 in patients. Visual evoked potentials were studied in response to visual stimulation paradigms with flashes of light. Following intensity\u2010dependent visual stimulation, FHM1 mutant mice displayed faster visual evoked potential responses, with lower initial amplitude, followed by less pronounced neuronal suppression compared to wild\u2010type mice. Similar to what was reported for migraine patients, frequency\u2010dependent stimulation in mutant mice revealed enhanced photic drive in the EEG beta\u2010gamma band. The frequency\u2010dependent increases in visual network responses in mutant mice may reflect the context\u2010dependent enhancement of visual cortex excitability, which could contribute to our understanding of sensory hypersensitivity in migraine.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15041","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T17:50:47Z","timestamp":1605030647000},"page":"1672-1686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Responsivity to light in familial hemiplegic migraine type 1 mutant mice reveals frequency\u2010dependent enhancement of visual network excitability"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3849-6975","authenticated-orcid":false,"given":"Matthijs J. 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