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The OX system prominently targets brain structures involved in the regulation of wake\u2013sleep state switching, and also orchestrates multiple physiological functions. The degeneration and dysregulation of the OX system promotes narcoleptic phenotypes both in humans and animals. Hence, this review begins with the already proven involvement of OX in narcolepsy, but it mainly discusses the new pre\u2010clinical and clinical insights of the role of OX in three major neurological disorders characterized by sleep impairment which have been recently associated with OX dysfunction, such as Alzheimer's disease, stroke and Prader Willi syndrome, and have been emerged over the past 10\u00a0years to be strongly associated with the OX dysfunction and should be more considered in the future. In the light of the impairment of the OX system in these neurological disorders, it is conceivable to speculate that the integrity of the OX system is necessary for a healthy functioning body.<\/jats:p>","DOI":"10.1111\/ejn.15077","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T03:52:54Z","timestamp":1607485974000},"page":"1136-1154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Dysregulation of the orexin\/hypocretin system is not limited to narcolepsy but has far\u2010reaching implications for neurological disorders"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-9445","authenticated-orcid":false,"given":"Chiara","family":"Berteotti","sequence":"first","affiliation":[{"name":"PRISM Lab Department of Biomedical and Neuromotor Sciences Alma Mater Studiorum \u2010 University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-1332","authenticated-orcid":false,"given":"Claudio","family":"Liguori","sequence":"additional","affiliation":[{"name":"Sleep Medicine Centre Neurology Unit University Hospital Tor Vergata Rome Italy"},{"name":"Department of Systems Medicine University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-4544","authenticated-orcid":false,"given":"Marta","family":"Pace","sequence":"additional","affiliation":[{"name":"Genetics and Epigenetics of Behaviour Laboratory Istituto Italiano di Tecnologia Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,24]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"American Academy of Sleep Medicine. 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