{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:01:26Z","timestamp":1790622086874,"version":"4.1.0"},"reference-count":139,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004497","name":"Onderzoeksraad, KU Leuven","doi-asserted-by":"publisher","award":["C14\/16\/048"],"award-info":[{"award-number":["C14\/16\/048"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G061216N"],"award-info":[{"award-number":["G061216N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["SB\/151597"],"award-info":[{"award-number":["SB\/151597"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["SB\/1S62920N"],"award-info":[{"award-number":["SB\/1S62920N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The endocannabinoid system has been linked to neurological disorders in which the excitation inhibition (E\/I) balance in the neocortex is dysregulated, such as schizophrenia. The main endocannabinoid receptor type 1 of the central nervous system\u2014CB1R\u2014is expressed on different cell types, that when activated, modulate the cortical E\/I balance. Here we review how CB1R signalling contributes to phases of heightened plasticity of the neocortex. We review the major role of the CB1R in cortical plasticity throughout life, including the early life sensory critical periods, the later maturation phase of the association cortex in adolescence, and the adult phase of sensory deprivation\u2010induced cortical plasticity. Endocannabinoid\u2010mediated long\u2010term potentiation and depression of synapse strength fine\u2010tune the E\/I balance in visual, somatosensory and association areas. We emphasize how a distinct set of key endocannabinoid\u2010regulated elements such as GABA and glutamate release, basket parvalbumin interneurons, somatostatin interneurons and astrocytes, are essential for normal cortical plasticity and dysregulated in schizophrenia. Even though a lot of data has been gathered, mechanistic knowledge about the exact CB1R\u2010based modulation of excitation and\/or inhibition is still lacking depending on cortical area and maturation phase in life. We emphasize the importance of creating such detailed knowledge for a better comprehension of what underlies the dysregulation of the neocortex in schizophrenic patients in adulthood. We propose that taking age, brain area and cell type into consideration when modulating the cortical\u00a0E\/I imbalance via cannabinoid\u2010based pharmacology may pave the way for better patient care.<\/jats:p>","DOI":"10.1111\/ejn.15110","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:51:07Z","timestamp":1610671867000},"page":"971-988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Endocannabinoids and cortical plasticity: CB1R as a possible regulator of the excitation\/inhibition balance in health and disease"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1386-5930","authenticated-orcid":false,"given":"Lucas J. A.","family":"Durieux","sequence":"first","affiliation":[{"name":"KU Leuven Department of Biology Laboratory of Neuroplasticity and Neuroproteomics  Leuven Belgium"},{"name":"Leuven Brain Institute  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-3877","authenticated-orcid":false,"given":"Sara R. J.","family":"Gilissen","sequence":"additional","affiliation":[{"name":"KU Leuven Department of Biology Laboratory of Neuroplasticity and Neuroproteomics  Leuven Belgium"},{"name":"Leuven Brain Institute  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2909-8449","authenticated-orcid":false,"given":"Lutgarde","family":"Arckens","sequence":"additional","affiliation":[{"name":"KU Leuven Department of Biology Laboratory of Neuroplasticity and Neuroproteomics  Leuven Belgium"},{"name":"Leuven Brain Institute  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15\u201017690"},{"key":"e_1_2_11_3_1","first-page":"e51936","article-title":"A highly reproducible and straightforward method to perform in vivo ocular enucleation in the mouse after eye opening","volume":"92","author":"Aerts J.","year":"2014","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3101-05.2006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016442108"},{"key":"e_1_2_11_6_1","unstructured":"Allen Institute for Brain Science. (2018).RNA\u2010Seq Data Navigator: Mouse. Retrived fromhttps:\/\/celltypes.brain\u2010map.org"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(87)92620\u20101"},{"key":"e_1_2_11_8_1","first-page":"449","article-title":"Maturation of the adolescent brain","volume":"9","author":"Arain M.","year":"2013","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7374.1212"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.6.3287"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201014198\u20108"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u20100602\u20101"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14103"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.12.029"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137406"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.03.035"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0442\u201005.2005"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2020.06.018"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.03.023"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010013\u20100508\u20108"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.05.013"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.14"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1851-04.2004"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30592"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.06.001"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0736\u201010.2010"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3484"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.06.009"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609596104"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306\u20104522(00)00552\u20102"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.11.033"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn2008"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3876"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2018.02.001"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2012.08075.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/35004582"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010016\u20109697\u20105"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2018.00037"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-05-01826.1992"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05558"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.050"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u20109861(19980601)395:2<209:AID\u2010CNE5>3.0.CO;2\u20106"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09060784"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2017.05.023"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306\u20104522(96)00428\u20109"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.04.030"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/723184"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu231"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-10-03274.1996"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.037"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-22-j0003.1999"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.01.004"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5554-05.2006"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1965"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24733"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163149"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23830"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1787"},{"key":"e_1_2_11_59_1","first-page":"11","article-title":"Re\u2010opening windows: Manipulating critical periods for brain development","volume":"2012","author":"Hensch T. K.","year":"2012","journal-title":"Cerebrum"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5393.1504"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00603.2006"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-20825-1_11"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12547"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4384\u201010.2010"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.571133"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.07.028"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.03.021"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2005.05.007"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep02093"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959\u20104388(02)00328\u20108"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000709"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.09.005"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.011"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910102"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010061010\u2010113813"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010018\u20100539\u2010z"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.10.005"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.10.018"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.04.034"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/254724"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx053"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711002078"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460\u20109568.1999.00847.x"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00457"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00544"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22773"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3075"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-18-08084.2002"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.09.014"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm186"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106257(99)00112\u20105"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803545105"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27345"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23455"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3808\u201014.2015"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.05.002"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.05.001"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4975\u201014.2015"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.05.027"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1247"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.03.003"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820836117"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.11.005"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756\u2010199302000\u201000005"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.015"},{"key":"e_1_2_11_106_1","first-page":"10","article-title":"Endocannabinoid system: Potential novel targets for treatment of schizophrenia","volume":"53","author":"Saito A.","year":"2013","journal-title":"Neurobiology of Disease, What Clinical Findings can Teach us about the Neurobiology of schizophrenia?"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.3917\/rep.016.0119"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8723623"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010018\u20101611\u20107"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.3934\/molsci.2019.1.27"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417\u2010009\u20101262\u20108"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-14-04322.1996"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.12.011"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.166"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.054"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12958"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0247\u201014.2014"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1192\/s0007125000293598"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1421844112"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl034"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001029"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq286"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065\u2010014\u20109248\u20107"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf043"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.09.005"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2016.01.003"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0336351100"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165\u20103806(02)00540\u20100"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230256"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/299583a0"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1965.28.6.1060"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2010.07337.x"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20100963\u20103"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2016.00076"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21962"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/581686"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053082"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802884744"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7374.1199"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1934"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.15110","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T07:52:14Z","timestamp":1692863534000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.15110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,6]]},"references-count":139,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/ejn.15110"],"URL":"https:\/\/doi.org\/10.1111\/ejn.15110","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,6]]},"assertion":[{"value":"2020-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}