{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:51:45Z","timestamp":1790848305918,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH108568"],"award-info":[{"award-number":["R01 MH108568"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Reductions of the auditory N100 are present in schizophrenia, even at the first episode (FESz). Because most studies examine auditory N100 on active target detection oddball tasks, it remains unclear if the abnormality in FESz results from sensory deficits or impaired enhancement of N100 by selective attention, or both. N100 was recorded from 21 FESz and 22 matched healthy controls (HC) on a single\u2010tone task and a two\u2010tone oddball task. Overall, N100 was smaller in FESz (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.036). Attention enhanced N100 amplitude (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.001), but this differed between groups, with FESz impaired in N100 modulation (group x attention,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.012). The oddball task showed greater N100 enhancement than the single\u2010tone task (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.001) in both groups. Group differences in N100 enhancement in the oddball task were large (Cohen's\n                    <jats:italic>d<\/jats:italic>\n                    \u00a0=\u00a00.85). Exploratory correlations showed that better N100 enhancement on the oddball task in FESz was associated with better MATRICS Overall Composite scores (cognitive tasks highly sensitive to psychosis), lower PANNS Negative factor and SANS scores, and better interpersonal (social) and role functioning in the last year. N100 during ignore conditions showed no significant difference between groups, albeit smaller in FESz, with small to medium effect sizes. Although sensory deficits in N100 are likely present, they are compounded by a failure to enhance N100 with attention. The failure of N100 enhancement by attentional gain control in FESz suggests functional dysconnection between cognitive control areas and the sensory cortex. N100 amplitude on active attention tasks may be a useful outcome biomarker for targeted enhancement of the cognitive control system.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15128","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T15:38:07Z","timestamp":1611589087000},"page":"2629-2638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Deficits in attentional modulation of auditory N100 in first\u2010episode schizophrenia"],"prefix":"10.1111","volume":"53","author":[{"given":"Xi","family":"Ren","sequence":"first","affiliation":[{"name":"Clinical Neurophysiology Research Laboratory Western Psychiatric Hospital Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah N.","family":"Fribance","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Research Laboratory Western Psychiatric Hospital Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Coffman","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Research Laboratory Western Psychiatric Hospital Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-0599","authenticated-orcid":false,"given":"Dean F.","family":"Salisbury","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Research Laboratory Western Psychiatric Hospital Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.04.015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.066"},{"key":"e_1_2_10_4_1","volume-title":"Dementia praecox, or the group of schizophrenias","author":"Bleuler E.","year":"1911"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2004.01.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.02.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20103223(85)90059\u20109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021\u2010843X.94.4.470"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.0623"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2014.11.012"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053\u2010198912000\u201000004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.04.038"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010010\u20100176\u20100"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013\u20104694(80)90222\u20109"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.182.4108.177"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/72999"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/155005949402500204"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15050632"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713000834"},{"issue":"9","key":"e_1_2_10_21_1","first-page":"18S","article-title":"Are schizophrenia patients amusical?: The role of pitch and rhythm in auditory emotion recognition impairments in schizophrenia","volume":"73","author":"Kantrowitz J. 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