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Repeated practice is essential to gain proficiency over time but may induce fatigue. The aim of this study was to determine whether motor performance and motor learning (as assessed with the serial reaction time task, SRTT) and perceived fatigability (as assessed with subjective scales) are improved after two types of placebo interventions (motor and cognitive). A total of 90 healthy volunteers performed the SRTT with the right hand in three sessions (baseline, training and final). Before the training and the final session, one group underwent a motor\u2010related placebo intervention in which inert electrical stimulation (TENS) was applied over the hand and accompanied by verbal suggestion that it improves movement execution (placebo\u2010TENS). The other group underwent a cognitive\u2010related placebo intervention in which sham transcranial direct current stimulation (tDCS) was delivered to the supraorbital area and accompanied by verbal suggestion that it increases attention (placebo\u2010tDCS). A control group performed the same task without receiving treatment. Overall better performance on the SRTT (not ascribed to sequence\u2010specific learning) was noted for the placebo\u2010TENS group, which also reported less perceived fatigability at the physical level. The same was observed in a subgroup tested 24\u00a0hr later. The placebo\u2010tDCS group reported less perceived fatigability, both at the mental and physical level. These findings indicate that motor\u2010 and cognitive\u2010related placebo effects differently shape motor performance and perceived fatigability on a repeated motor task.<\/jats:p>","DOI":"10.1111\/ejn.15148","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T14:38:42Z","timestamp":1613399922000},"page":"2655-2668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The effect of motor and cognitive placebos on the serial reaction time task"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-1936","authenticated-orcid":false,"given":"Bernardo","family":"Villa\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Emadi 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