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Today it is clear that the nociceptive system, even if still immature, is functional enough in the newborn infant to elicit pain responses. Unfortunately, pain is often present in the neonatal period, in particular in the case of premature infants which are subjected to a high number of painful procedures during care. These are accompanied by a variety of environmental stressors, which could impact the maturation of the nociceptive system. Therefore, the question of the long\u2010term consequences of early life stress is a critical question. Early stressful experience, both painful and non\u2010painful, can imprint the nociceptive system and induce long\u2010term alteration in brain function and nociceptive behavior, often leading to an increase sensitivity and higher susceptibility to chronic pain. Different animal models have been developed to understand the mechanisms underlying the long\u2010term effects of different early life stressful procedures, including pain and maternal separation. This review will focus on the clinical and preclinical data about early life stress and its consequence on the nociceptive system.<\/jats:p>","DOI":"10.1111\/ejn.15153","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T03:17:15Z","timestamp":1613963835000},"page":"2216-2241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["The burden of early life stress on the nociceptive system development and pain responses"],"prefix":"10.1111","volume":"55","author":[{"given":"Meggane","family":"Melchior","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique and University of Strasbourg Institut des Neurosciences Cellulaires et Int\u00e9gratives  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique and University 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