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While traumatic, persistent or multiregional pain models are commonly considered more effective in inducing negative affect or functional impairment, the early psychobehavioral changes before pain chronification are often underexplored. Here, we aimed to clarify the fundamental relationship between hypernociception and passive distress\u2010like behavior using a model of transient inflammatory pain. To minimize latent confounders and increase data consistency, male C57BL\/6N mice were habituated to the open\u2010field arena 6 times before receiving the unilateral intraplantar injection of prostaglandin E2 (PGE2) or vehicle. Open\u2010field (40\u2010min exploration) and nociceptive behavior were evaluated repeatedly along the course of hypernociception in both wild\u2010type and transgenic mice with a known pronociceptive phenotype. To reduce subjectivity, multivariate open\u2010field behavioral outcomes were analyzed by statistical modeling based on exploratory factor analyses, which yielded a 2\u2010factor solution. Within 3\u00a0hr after PGE2 injection, mice developed significantly reduced center exploration (factor 1) and a marginally significant increase in their habituation tendency (factor 2), which were not apparent in vehicle\u2010injected mice. The behavioral passivity generally improved as hypernociception subsided. Therefore, transient inflammatory irritation is sufficient to suppress mouse open\u2010field exploratory activity. The apparent absence of late affective\u2010motivational changes in some rodents with prolonged hypernociception may not imply a lack of preceding or underlying neuropsychological alterations. Procedural pain after invasive animal experiments, however small, should be assessed and adequately controlled as a potential research confounder.<\/jats:p>","DOI":"10.1111\/ejn.15174","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T03:31:48Z","timestamp":1615001508000},"page":"3072-3092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characterization of acute pain\u2010induced behavioral passivity in mice: Insights from statistical modeling"],"prefix":"10.1111","volume":"53","author":[{"given":"Sung Ching","family":"Yeung","sequence":"first","affiliation":[{"name":"Laboratory and Clinical Research Institute for Pain Department of Anaesthesiology The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Laboratory and Clinical Research Institute for Pain 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