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This study investigated the potential of microbe\u2010induced gut\u2010to\u2010brain signaling to modulate the effect of stress on depressive\u2010like behavior, intestinal barrier, and neuroinflammation. Result showed that fecal microbiota transplantation increased the consumption of sucrose solutions and decreased the immobility time in forced swimming test. This treatment also increased\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    and decreased\n                    <jats:italic>Bacteroidetes<\/jats:italic>\n                    and\n                    <jats:italic>Desulfobacterota<\/jats:italic>\n                    at phylum levels; reduced the loss of villi and epithelial cells; suppressed the inflammatory cell infiltration in the ileum; increased the expression of ZO\u20101, occludin; protected the mucosal layer function; and suppressed the high levels of inflammasomes (\n                    <jats:italic>NLRP3<\/jats:italic>\n                    ,\n                    <jats:italic>ASC<\/jats:italic>\n                    ,\n                    <jats:italic>caspase\u20101<\/jats:italic>\n                    , and\n                    <jats:italic>IL\u20101\u03b2<\/jats:italic>\n                    ) in rat brain. In summary, fecal microbiota transplantation improves the depressive\u2010like behavior, alters the gut microbiota imbalance, and alleviates the intestinal tract inflammation, intestinal mucosa disruption, and neuroinflammation in rats induced by chronic unpredictable mild stress.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15192","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T08:05:53Z","timestamp":1616227553000},"page":"3598-3611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress\u2010induced depressive\u2010like behavior"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4148-8474","authenticated-orcid":false,"given":"Jingjing","family":"Rao","sequence":"first","affiliation":[{"name":"Cheeloo College of Medicine 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