{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:38:36Z","timestamp":1785868716575,"version":"3.56.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Emotion regulation is related to recovery after mild traumatic brain injury (mTBI). This longitudinal tractography study examined white matter tracts subserving emotion regulation across the spectrum of mTBI, with a focus on persistent symptoms. Four groups were examined: (a) symptomatic (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a033) and (b) asymptomatic (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020) patients with uncomplicated mTBI (i.e., no lesions on computed tomography [CT]), (c) patients with CT\u2010lesions in the frontal areas (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a014), and (d) healthy controls (HC) (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020). Diffusion and conventional MRI were performed approximately 1\u2010 and 3\u2010months post\u2010injury. Whole\u2010brain deterministic tractography followed by region of interest analyses was used to identify forceps minor (FM), uncinate fasciculus (UF), and cingulum bundle as tracts of interest. An adjusted version of the ExploreDTI Atlas Based Tractography method was used to obtain reliable tracts for every subject. Mean fractional anisotropy (FA), mean, radial and axial diffusivity (MD, RD, AD), and number of streamlines were studied per tract. Linear mixed models showed lower FA, and higher MD, and RD of the right UF in asymptomatic patients with uncomplicated mTBI relative to symptomatic patients and HC. Diffusion alterations were most pronounced in the group with frontal lesions on CT, particularly in the FM and UF; these effects increased over time. Within the group of patients with uncomplicated mTBI, there were no associations of diffusion measures with the number of symptoms nor with lesions on conventional MRI. In conclusion, mTBI can cause microstructural changes in emotion regulation tracts, however, no explanation was found for the presence of symptoms.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15199","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:46Z","timestamp":1616544046000},"page":"3463-3475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["White matter microstructure of the neural emotion regulation circuitry in mild traumatic brain injury"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-0866","authenticated-orcid":false,"given":"Harm Jan","family":"van der Horn","sequence":"first","affiliation":[{"name":"Department of Neurology University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata R.","family":"Mangina","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Rakers","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelmer G.","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke E.","family":"Timmerman","sequence":"additional","affiliation":[{"name":"Department of Psychometrics and Statistics University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Leemans","sequence":"additional","affiliation":[{"name":"Image Sciences Institute University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacoba M.","family":"Spikman","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joukje","family":"van der Naalt","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.04.021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.21.5.515"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2008.05.004"},{"key":"e_1_2_9_7_1","article-title":"Structural connections support emotional connections: Uncinate Fasciculus microstructure is related to the ability to decode facial emotion expressions","volume":"145","author":"Coad B. M.","year":"2017","journal-title":"Neuropsychologia"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2016.04.036"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3337"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2014.08.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01406373"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00348"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.03.176"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47175"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-016-0253-y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2087"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13628-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.200810425"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.09.017"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu095"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/415740"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.1059"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.44.4.285"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2012.11.018"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038272"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2020.1841118"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001199-199309000-00010"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101842"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2009.2035616"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.053"},{"key":"e_1_2_9_32_1","unstructured":"Leemans A. Jeurissen B. Sijbers J. &Jones D.(2009).ExploreDTI: A graphical toolbox for processing analyzing and visualizing diffusion MR data. In: 17th Annual Meeting of Intl Soc Mag Reson Med. p.3537."},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.0245"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d0ccdd"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004214"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21785"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.03.010"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06751.x"},{"key":"e_1_2_9_39_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2020"},{"key":"e_1_2_9_40_1","first-page":"50","article-title":"Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer\u2019s disease","volume":"7","author":"Shamonin D. P.","year":"2014","journal-title":"Frontiers in Neuroinformatics"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27249"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.07.067"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70120-6"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010148"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.02.016"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-017-9743-6"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4659"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.3905"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09335-8"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24827"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30117-5"},{"key":"e_1_2_9_52_1","volume-title":"Intelligence and age: Study with Dutch people from age 12 to 77","author":"Verhage F.","year":"1964"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2170"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.02.049"},{"key":"e_1_2_9_55_1","first-page":"1","article-title":"A prospective biopsychosocial study of the persistent post\u2010concussion symptoms following mild traumatic brain injury","volume":"547","author":"W\u00e4ljas M.","year":"2014","journal-title":"Journal of Neurotrauma"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24939"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199009000-00014"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009930"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.15199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:31:19Z","timestamp":1693355479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.15199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,2]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/ejn.15199"],"URL":"https:\/\/doi.org\/10.1111\/ejn.15199","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.15199\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15199\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15199\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15199\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15199\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15199\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15199\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15199\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15199\/v2\/review1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,2]]},"assertion":[{"value":"2020-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}