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The mu opioid receptor plays a major role in drug reward. This receptor is modulated by chronic cocaine treatment in specific brain structures, but few studies investigated neurochemical adaptations induced by voluntary cocaine intake. In this study, we investigated whether intravenous cocaine\u2010self administration (0.33\u00a0mg\/kg\/injection, fixed\u2010ratio 1 [FR1], 10\u00a0days) in rats induces transcriptional and functional changes of the mu opioid receptor in reward\u2010related brain regions. Epigenetic processes with histone modifications were examined for two activating marks, H3K4Me3, and H3K27Ac. We found an increase of mu opioid receptor gene expression along with a potentiation of its functionality in hippocampus of cocaine self\u2010administering animals compared to saline controls. Chromatin immunoprecipitation followed by qPCR revealed no modifications of the histone mark H3K4Me3 and H3K27Ac levels at mu opioid receptor promoter. Our study highlights the hippocampus as an important target to further investigate neuroadaptive processes leading to cocaine addiction.<\/jats:p>","DOI":"10.1111\/ejn.15217","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T11:47:09Z","timestamp":1617450429000},"page":"3341-3349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hippocampal mu opioid receptors are modulated following cocaine self\u2010administration in rat"],"prefix":"10.1111","volume":"53","author":[{"given":"David","family":"De Sa Nogueira","sequence":"first","affiliation":[{"name":"Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA UMR7364) Centre de la Recherche Nationale Scientifique Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Bourdy","sequence":"additional","affiliation":[{"name":"Laboratoire de Neurosciences 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