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In humans, early\u2010life adversity (ELA) such as trauma, neglect, and resource scarcity are linked with increased risk of later\u2010life addiction, but the brain mechanisms underlying this link are still poorly understood. Here, we focus on data from rodent models of ELA and addiction, in which causal effects of ELA on later\u2010life responses to drugs and the neurodevelopmental mechanisms by which ELA increases vulnerability to addiction can be determined. We first summarize evidence for a link between ELA and addiction in humans, then describe how ELA is commonly modeled in rodents. Since addiction is a heterogeneous disease with many individually varying behavioral aspects that may be impacted by ELA, we next discuss common rodent assays of addiction\u2010like behaviors. We then summarize the specific addiction\u2010relevant behavioral phenotypes caused by ELA in male and female rodents and discuss some of the underlying changes in brain reward and stress circuits that are likely responsible. By better understanding the behavioral and neural mechanisms by which ELA promotes addiction vulnerability, we hope to facilitate development of new approaches for preventing or treating addiction in those with a history of ELA.<\/jats:p>","DOI":"10.1111\/ejn.15223","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T03:41:20Z","timestamp":1617766880000},"page":"2170-2195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Neurodevelopmental origins of substance use disorders: Evidence from animal models of early\u2010life adversity and addiction"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-4924","authenticated-orcid":false,"given":"Sophia C.","family":"Levis","sequence":"first","affiliation":[{"name":"Department of Anatomy &amp; Neurobiology University of California Irvine  Irvine CA USA"},{"name":"Department of Neurobiology &amp; Behavior University of California Irvine  Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0771-8616","authenticated-orcid":false,"given":"Tallie Z.","family":"Baram","sequence":"additional","affiliation":[{"name":"Department of Anatomy &amp; Neurobiology University of California Irvine  Irvine CA USA"},{"name":"Department of Pediatrics University of California Irvine  Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-0905","authenticated-orcid":false,"given":"Stephen V.","family":"Mahler","sequence":"additional","affiliation":[{"name":"Department of Neurobiology &amp; Behavior University of California Irvine  Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,25]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.08.011"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.09.027"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893\u2010133X(99)00133\u20105"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/1127008"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.08.002"},{"key":"e_1_2_14_7_1","unstructured":"American Psychological Association. 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