{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:11:44Z","timestamp":1787314304049,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008733","name":"H\u00f8rslev-Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006316","name":"Drug Research Academy, K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R133\u2010A12270"],"award-info":[{"award-number":["R133\u2010A12270"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R230\u20102016\u20102562"],"award-info":[{"award-number":["R230\u20102016\u20102562"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R277\u20102018\u2010260"],"award-info":[{"award-number":["R277\u20102018\u2010260"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    \u03b3\u2010Aminobutyric acid (GABA) acting through heteropentameric GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors plays a pivotal role in the sleep\u2010promoting circuitry. Whereas the role of the different GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor \u03b1\u2010subunits in sleep regulation and in mediating the effect of benzodiazepines for treatment of insomnia is well\u2010described, the \u03b2\u2010subunits are less studied. Here we report the first study characterizing sleep in mice lacking the GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    \u2010subunit (\u03b2\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice). We show that \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice have a distinct and abnormal sleep phenotype characterized by increased delta power in non\u2010rapid eye movement (NREM) sleep and decreased theta activity in rapid eye movement (REM) sleep compared to \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>+\/+<\/jats:sup>\n                    mice, without any change in the overall sleep\u2010wake architecture. From GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor\u2010specific autoradiography, it is further demonstrated that functional \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    \u2010subunit\u2010containing GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors display the highest binding levels in the hippocampus and frontal cortex. In conclusion, this study suggests that the GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    \u2010subunit does not play an important role in sleep initiation or maintenance but instead regulates the power spectrum and especially the expression of theta rhythm. This provides new knowledge on the complex role of GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor subunits in sleep regulation. In addition, \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice could provide a useful mouse model for future studies of the physiological role of delta and theta rhythms during sleep.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15267","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T22:10:21Z","timestamp":1620079821000},"page":"4445-4455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["GABA\n                    <sub>A<\/sub>\n                    receptor \u03b2\n                    <sub>1<\/sub>\n                    \u2010subunit knock\u2010out mice show increased delta power in NREM sleep and decreased theta power in REM sleep"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-9125","authenticated-orcid":false,"given":"Maria Elena Klibo","family":"Lie","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8576-9406","authenticated-orcid":false,"given":"Christina Birkedahl","family":"Falk\u2010Petersen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-5996","authenticated-orcid":false,"given":"Louise","family":"Piilgaard","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0897-6692","authenticated-orcid":false,"given":"Nane","family":"Griem\u2010Krey","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-8013","authenticated-orcid":false,"given":"Petrine","family":"Wellendorph","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2515-9451","authenticated-orcid":false,"given":"Birgitte Rahbek","family":"Kornum","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3816"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5252"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.203"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15146"},{"key":"e_1_2_10_7_1","first-page":"318543","article-title":"Kinase activity simultaneously determines the constitutive and the orthosteric gating in \u03b14\u03b21\/3\u03b4 GABAA receptors in hippocampal granule cells","author":"Dalby N.","year":"2018","journal-title":"bioRxiv"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40140-013-0046-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12778"},{"key":"e_1_2_10_10_1","first-page":"29","article-title":"Effects of housing condition and cage change on characteristics of sleep in mice","volume":"53","author":"Febinger H. 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