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This raises the possibility that drug addiction treatments may show utility in the treatment of compulsive overeating. N\u2010Acetylcysteine (NAC) is a cysteine pro\u2010drug which has experienced some success in clinical trials, reducing cocaine, marijuana and cigarette use, as well as compulsive behaviours such as gambling and trichotillomania. We assessed the impact of NAC on addiction\u2010like behaviour towards highly palatable food in a rat model of diet\u2010induced obesity. Adult male Sprague\u2013Dawley rats were placed on a high\u2010fat high\u2010sugar diet for 8\u00a0weeks and then assigned to diet\u2010induced obesity\u2010prone (DIO) or diet\u2010induced obesity\u2010resistant (DR) groups based on weight gain. DIO and DR rats were subjected to an operant conditioning paradigm whereby rats could lever press for high\u2010fat high\u2010sugar food pellets. This alternated with periods of signalled reward unavailability. Before treatment DIO rats ate more in their home cage, earned more food pellets in operant sessions, and responded more during periods that signalled reward unavailability (suggestive of compulsive\u2010like food seeking) compared with DR rats. This persistent responding in the absence of reward displayed by DIO rats was ameliorated by daily injections of NAC (100\u00a0mg\/kg, i.p.) for 14\u00a0days. By the end of the treatment period, lever\u2010pressing by NAC\u2010treated DIO rats resembled that of DR rats. These findings suggest that NAC reduces addiction\u2010like behaviour towards food in rats and supports the potential use of this compound in compulsive overeating.<\/jats:p>","DOI":"10.1111\/ejn.15321","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T10:41:43Z","timestamp":1621852903000},"page":"4877-4887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["N\u2010acetylcysteine reduces addiction\u2010like behaviour towards high\u2010fat high\u2010sugar food in diet\u2010induced obese rats"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-042X","authenticated-orcid":false,"given":"Diana","family":"Sketriene","sequence":"first","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Mental Health Research Theme  Parkville\/Melbourne Victoria Australia"},{"name":"The Florey Department of Neuroscience and Mental Health 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