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In this review, we discuss current insights into the spread of \u03b1\u2010synuclein pathology along the gut\u2013brain axis, which could be targeted for therapeutic interventions. The prion\u2010like propagation of \u03b1\u2010synuclein, and the clinical manifestations of gastrointestinal dysfunction in individuals living with PD, are discussed. There is currently insufficient evidence that surgical alteration of the vagus nerve, or removal of gut\u2010associated lymphoid tissues, such as the appendix and tonsils, are protective against PD. Furthermore, we propose curcumin as a potential candidate to prevent the spread of \u03b1\u2010synuclein pathology in the body by curcumin binding to \u03b1\u2010synuclein's non\u2010amyloid \u03b2\u2010component (NAC) domain. Curcumin is an active component of the food spice turmeric and is known for its antioxidant, anti\u2010inflammatory, and potentially neuroprotective properties. We hypothesize that once \u03b1\u2010synuclein is bound to curcumin, both molecules are subsequently excreted from the body. Therefore, dietary supplementation with curcumin over one's lifetime has potential as a novel approach to complement existing PD treatment and\/or prevention strategies. Future studies are required to validate this hypothesis, but if successful, this could represent a significant step towards improved nutrient\u2010based therapeutic interventions and preventative strategies for this debilitating and currently incurable disorder.<\/jats:p>","DOI":"10.1111\/ejn.15324","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T13:37:20Z","timestamp":1622122640000},"page":"4695-4711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Movement of prion\u2010like \u03b1\u2010synuclein along the gut\u2013brain axis in Parkinson's disease: A potential target of curcumin treatment"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-3696","authenticated-orcid":false,"given":"Devina","family":"Chetty","sequence":"first","affiliation":[{"name":"Division of Molecular Biology and Human Genetics Faculty of Medicine and Health 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