{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:43:31Z","timestamp":1772160211709,"version":"3.50.1"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007135","name":"University of Tennessee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007135","name":"University of Tennessee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15MH124042"],"award-info":[{"award-number":["R15MH124042"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rodent dams seek and gather scattered pups back to the nest (pup retrieval), an essential aspect of maternal care. Systematic analysis of the dynamic sequences of goal\u2010related movements that comprise the entire behavioural sequence, which would be ultimately essential for understanding the underlying neurobiology, is not well\u2010characterized. Here, we present such analysis across 3\u00a0days in alloparental female mice (Surrogates or Sur) of two genotypes;\n                    <jats:italic>\n                      Mecp2\n                      <jats:sup>Heterozygotes<\/jats:sup>\n                    <\/jats:italic>\n                    (Het), a female mouse model for Rett syndrome and their wild type (WT) siblings. We analysed CBA\/CaJ and C57BL\/6J WT surrogates for within\u2010strain comparisons. Frame\u2010by\u2010frame analysis over different phases was performed manually using DataVyu software. We previously showed that surrogate Het are inefficient at pup retrieval, by end\u2010point analysis such as latency index and errors. Here, the sequence of searching, pup\u2010approach and successful retrieval streamlines over days for WT, while Het exhibits variations in this pattern. Goal\u2010related movements between Het and WT are similar in other phases, suggesting context\u2010driven atypical patterns in Het during the pup retrieval phase. We identified proximal pup approach and pup grooming as atypical tactile interactions between pups and Het. Day\u2010by\u2010day analysis showed dynamic changes in goal\u2010related movements in individual animals across genotypes and strains. Overall, our approach (1) highlights natural variation in individual mice on different days, (2) establishes a \u201cgold\u2010standard\u201d manually curated dataset to help build behavioural repertoires using machine learning approaches, and (3) suggests atypical tactile sensory processing and possible regression in a female mouse model for Rett syndrome.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15327","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T13:39:24Z","timestamp":1622122764000},"page":"4528-4549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Systematic analysis of goal\u2010related movement sequences during maternal behaviour in a female mouse model for Rett syndrome"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4208-6426","authenticated-orcid":false,"given":"Parker K.","family":"Stevenson","sequence":"first","affiliation":[{"name":"Department of Biochemistry &amp; Cellular and Molecular Biology University of Tennessee Knoxville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-8770","authenticated-orcid":false,"given":"Devin M.","family":"Casenhiser","sequence":"additional","affiliation":[{"name":"Audiology and Speech Pathology Department University of Tennessee Health Sciences Center Knoxville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2380-5341","authenticated-orcid":false,"given":"Billy Y. 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