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Depression in this frequency range is thought of as a possible contributor to behavioural habituation. In fact, in contrast to the proximal synapses, the distal synapses provide more direct sensory information from the entorhinal cortex as well as from thalamic nuclei. The use of antagonists showed that the activation of GABA\n                    <jats:sub>A<\/jats:sub>\n                    , GABA\n                    <jats:sub>B<\/jats:sub>\n                    , NMDA, mGlu, kainate, adenosine, or endocannabinoid receptors was not directly involved in the depression, indicating it to be intrinsic to the synapses themselves. While the depression affected paired\u2010pulse plasticity in a manner indicating a decrease in vesicle release probability, the depression could not be explained by a stimulus\u2010dependent decrease in calcium influx. Despite affecting the synaptic response evoked by brief high\u2010frequency stimulation (10 impulses, 20\u2009Hz) in a manner indicating vesicle depletion, the depression was unaffected by large variations in release probability. The depression was found not only to affect the synaptic transmission at low frequencies (0.1\u20131\u2009Hz) but also to contribute to the depression evolving during brief high\u2010frequency stimulation (10 impulses, 20\u2009Hz). We propose that a release\u2010independent process directly inactivating release sites with a fast onset (ms) and long duration (up to 20\u2009s) underlies this synaptic depression.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15357","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T21:49:20Z","timestamp":1623880160000},"page":"4838-4862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Homosynaptic frequency\u2010dependent depression by release site inactivation at neonatal hippocampal synapses in the stratum lacunosum\u2010moleculare"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-2812","authenticated-orcid":false,"given":"Rong","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg 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