{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:38:34Z","timestamp":1791308314395,"version":"4.3.1"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The functional anatomy of the anteromesial portion of the temporal lobe and its involvement in epilepsy can be explored by means of intracerebral electrical stimulations. Here, we aimed to expand the knowledge of its physiological and pathophysiological symptoms by conducting the first large\u2010sample systematic analysis of 1529 electrical stimulations of this anatomical region. We retrospectively analysed all clinical manifestations induced by intracerebral electrical stimulations in 173 patients with drug\u2010resistant focal epilepsy with at least one electrode implanted in this area. We found that high\u2010frequency stimulations were more likely to evoke electroclinical manifestations (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001) and also provoked \u2018false positive\u2019 seizures. Multimodal symptoms were associated with EEG electrical modification (after discharge) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001). Visual symptoms were not associated with after discharge (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0002) and were mainly evoked by stimulation of the hippocampus (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.009) and of the parahippocampal gyrus (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0212). \u2018False positive seizures\u2019 can be evoked by stimulation of the hippocampus, parahippocampal gyrus and amygdala, likely due to their intrinsic low epileptogenic threshold. Visual symptoms evoked in the hippocampus and parahippocampal gyrus, without EEG changes, are physiological symptoms and suggest involvement of these areas in the visual ventral stream. Our findings provide meaningful guidance in the interpretation of intracranial EEG studies of the temporal lobe.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15377","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T05:43:35Z","timestamp":1625118215000},"page":"5368-5383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Intracerebral electrical stimulations of the temporal lobe: A stereoelectroencephalography study"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0476-2283","authenticated-orcid":false,"given":"Valeria","family":"Mariani","sequence":"first","affiliation":[{"name":"Neurology and Stroke Unit Divison Circolo Hospital ASST Settelaghi University of Insubria  Varese Italy"},{"name":"\"Claudio Munari\" Epilepsy Surgery Centre ASST GOM Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5639-1969","authenticated-orcid":false,"given":"Simona","family":"Balestrini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology and Chalfont Centre for Epilepsy  London UK"},{"name":"Neuroscience Department Meyer Children's Hospital\u2014University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gozzo","sequence":"additional","affiliation":[{"name":"\"Claudio Munari\" Epilepsy Surgery Centre ASST GOM Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Pelliccia","sequence":"additional","affiliation":[{"name":"\"Claudio Munari\" Epilepsy Surgery Centre ASST GOM Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Mai","sequence":"additional","affiliation":[{"name":"\"Claudio Munari\" Epilepsy Surgery Centre ASST GOM Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0577-5193","authenticated-orcid":false,"given":"Stefano","family":"Francione","sequence":"additional","affiliation":[{"name":"\"Claudio Munari\" Epilepsy Surgery Centre ASST GOM Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5659-0730","authenticated-orcid":false,"given":"Ivana","family":"Sartori","sequence":"additional","affiliation":[{"name":"\"Claudio Munari\" Epilepsy Surgery Centre ASST GOM Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5141-9202","authenticated-orcid":false,"given":"Francesco","family":"Cardinale","sequence":"additional","affiliation":[{"name":"\"Claudio Munari\" Epilepsy Surgery Centre ASST GOM Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0632-7296","authenticated-orcid":false,"given":"Laura","family":"Tassi","sequence":"additional","affiliation":[{"name":"\"Claudio Munari\" Epilepsy Surgery Centre ASST GOM Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470114759.ch5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-015-0511-6"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv187"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.03.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000137037.56916.3F"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.06.005"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00591-0"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703784"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1984.tb04157.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2009_7"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e31827d1161"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.2.FOCUS16539"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz196"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy219"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.07.001"},{"key":"e_1_2_12_17_1","first-page":"199","article-title":"What stimulation of the supplementary motor area in humans tells about its functional organization","volume":"70","author":"Chauvel P. Y.","year":"1996","journal-title":"Advances in Neurology"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.02.008"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1464"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2018.02.016"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2008.07.004"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1954.02330050075012"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.2.397"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-020-0910-1"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2018.03.019"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200010)48:4<614::AID-ANA8>3.0.CO;2-S"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02448.x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0528"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws277"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl041"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.06.009"},{"key":"e_1_2_12_34_1","volume-title":"Atlas of the human brain","author":"Mai J. K.","year":"2008"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.09704.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.07.014"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00877.x"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.6.1013"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4048-13.2014"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01066.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1959.02340150001001"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-9297-9_42"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0370-4475(85)80011-3"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1545-8"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carj.2014.12.006"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm052"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.00695"},{"issue":"1","key":"e_1_2_12_48_1","first-page":"S23","article-title":"Direct electrical stimulations of the temporal pole in human","volume":"4","author":"Ostrowsky K.","year":"2002","journal-title":"Epileptic Disorders"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-195407000-00024"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.09.004"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2010.00046"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199501000-00001"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000313"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-322469"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl329"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.31101.x"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.19.1690"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.15377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:11:07Z","timestamp":1692850267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.15377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,26]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/ejn.15377"],"URL":"https:\/\/doi.org\/10.1111\/ejn.15377","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.15377\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15377\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15377\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15377\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15377\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,26]]},"assertion":[{"value":"2020-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}