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However, the central neural mechanism underlying PE patients with anxiety remains unclear. Resting\u2010state functional magnetic resonance imaging (fMRI) data were collected in 20 PE (diagnoses based on PE Guidelines drafted by the International Society for Sexual Medicine [ISSM]) patients with anxiety and 25 matched healthy controls (HCs) from January 2019 to December 2020. The values of fractional amplitude of low\u2010frequency fluctuation (fALFF) were compared between groups. Moreover, the correlations between fALFF and the severity of PE and anxiety of patients were examined. PE patients with anxiety had increased fALFF values in the right inferior frontal gyrus (opercular part) and middle frontal gyrus. In addition, significant positive correlations were found between the scores of PE diagnostic tool (PEDT) and fALFF values of the right inferior frontal gyrus (opercular part), as well as the right middle frontal gyrus. Moreover, fALFF values of the right inferior frontal gyrus (opercular part) and middle frontal gyrus were positively correlated with the scores of self\u2010rating anxiety scale (SAS). Our results suggested that increased attentional network activity might play a critical role in the neural basis of PE patients with anxiety.<\/jats:p>","DOI":"10.1111\/ejn.15402","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T21:46:13Z","timestamp":1627595173000},"page":"5417-5426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Increased attentional network activity in premature ejaculation patients with anxiety revealed by resting\u2010state functional magnetic resonance imaging"],"prefix":"10.1111","volume":"54","author":[{"given":"Shaowei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology, Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing 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