{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:23:27Z","timestamp":1789615407482,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>White matter hyperintensities (WMH) are common findings that can be found in physiological ageing. Several studies suggest that the disruption of white matter tracts included in WMH could induce abnormal functioning of the respective linked cortical structures, with consequent repercussion on the cerebral functions, included the cognitive sphere. In this cross\u2010sectional research, we analysed the effects of the total WMH burden (tWMHb) on resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI) and cognition. Functional and structural MR data, as well as the scores of the trail making test subtests A (TMT\u2010A) and B (TMT\u2010B) of 75 healthy patients, were extracted from the public available Leipzig Study for Mind\u2013Body\u2013Emotion Interactions dataset. tWMHb was extracted from structural data. Spearman's correlation analyses were made for investigating correlations between WMHb and the scores of the cognitive tests. The fractional amplitude of low\u2010frequency fluctuations (fALFF) method was applied for analysing the rs\u2010fMRI data, adopting a multiple regression model for studying the effects of tWMHb on brain activity. Three different subanalyses were conducted using different statistical methods. We observed statistically significant correlations between WMHb and the scores of the cognitive tests. The fALFF analysis revealed that tWMHb is associated with the reduction of regional neural activity of several brain areas (in particular the prefrontal cortex, precuneus and cerebellar crus I\/II). We conclude that our findings clarify better the relationships between WMH and cognitive impairment, evidencing that tWMHb is associated with impairments of the neurocognitive function in healthy subjects by inducing a diffuse reduction of the neural activity.<\/jats:p>","DOI":"10.1111\/ejn.15403","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T22:15:01Z","timestamp":1627596901000},"page":"5427-5443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The association between white matter hyperintensities, cognition and regional neural activity in healthy subjects"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3090-8541","authenticated-orcid":false,"given":"Michele","family":"Porcu","sequence":"first","affiliation":[{"name":"Department of Radiology, AOU Cagliari University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Cocco","sequence":"additional","affiliation":[{"name":"Department of Radiology, AOU Cagliari University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0300-5160","authenticated-orcid":false,"given":"Sirio","family":"Cocozza","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University of Napoli \u201cFederico II\u201d  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pontillo","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University of Napoli \u201cFederico II\u201d  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annunziata","family":"Operamolla","sequence":"additional","affiliation":[{"name":"Department of Radiology, AOU Cagliari University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Defazio","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasjit S.","family":"Suri","sequence":"additional","affiliation":[{"name":"Stroke Diagnosis and Monitoring Division, AtheroPoint\u2122  Roseville California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology University of Napoli \u201cFederico II\u201d  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Radiology, AOU Cagliari University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.308"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","unstructured":"Balsters J. 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