{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:51:47Z","timestamp":1782834707281,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060243"],"award-info":[{"award-number":["82060243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001604"],"award-info":[{"award-number":["82001604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neonatal hypoxic\u2013ischaemic (HI) injury is a serious complication of neonatal asphyxia and the leading cause of neonatal acute death and chronic neurological injury, and the effective therapeutic method is lacking to improve patients' outcomes. We reported in this study that panax notoginseng saponin (PNS) may provide a treatment option for HI. HI model was established using neonatal Sprague\u2013Dawley rats and then intraperitoneally injected with different dosage of PNS, once a day for 7\u00a0days. Histological staining and behavioural evaluations were performed to elucidate the pathological changes and neurobehavioural variation after PNS treatment. We found PNS administration significantly reduced the infarct volume of brain tissues and improved the autonomous activities of neonatal rats, especially with higher dosage. PNS treatment at 40\u2009mg\/kg reduced neuronal damage, suppressed neuronal apoptosis and depressed astroglial reactive response. Moreover, the long\u2010term cognitive and motor functions were also improved after PNS treatment at 40\u2009mg\/kg. Importantly, PNS treatment elevated the levels of BDNF and TrkB but decreased the expression of p75NTR both in the cortex and hippocampus of HI rats. The therapeutic efficacy of PNS might be correlated with PNS\u2010activated BDNF\/TrkB signalling and inactivation of p75NTR expression, providing a novel potential therapy for alleviating HI injury.<\/jats:p>","DOI":"10.1111\/ejn.15428","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T22:26:32Z","timestamp":1629239192000},"page":"6304-6321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Panax notoginseng saponin attenuates the hypoxic\u2013ischaemic injury in neonatal rats by regulating the expression of neurotrophin factors"],"prefix":"10.1111","volume":"54","author":[{"given":"Jin","family":"Huang","sequence":"first","affiliation":[{"name":"Institute of Neuroscience, School of Preclinical Medicine Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Xin","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, School of Preclinical Medicine Kunming Medical University  Kunming China"},{"name":"Department of Pediatrics The PLA Rocket Force Characteristic Medical Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u2010Lu","family":"Xue","sequence":"additional","affiliation":[{"name":"Animal Zoology Department Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo\u2010Lan","family":"Du","sequence":"additional","affiliation":[{"name":"Animal Zoology Department Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Jin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu\u2010Lin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Traditional Chinese Medicine Hospital Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2012-8936","authenticated-orcid":false,"given":"Ting\u2010Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Animal Zoology Department Kunming Medical University  Kunming China"},{"name":"Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"9","article-title":"Ischemic conditioning and neonatal hypoxic ischemic encephalopathy: A literature review","volume":"1","author":"Adstamongkonkul D.","year":"2017","journal-title":"Conditioning Medicine"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.nainr.2011.07.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.01.055"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90040-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60549-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00260-w"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.3030460322"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8080147"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17469899.2017.1269602"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.025"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.03.009"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201600493"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1982-13.2014"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.10.034"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.09.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S201135"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"issue":"7","key":"e_1_2_11_19_1","first-page":"847","article-title":"Update on pharmacological strategies for stroke: Prevention, acute intervention and regeneration","volume":"4","author":"Legos J. J.","year":"2003","journal-title":"Current Opinion in Investigational Drugs"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.19.030196.001445"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.84"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3505"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16065"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.10.004"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90007-4"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22419"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0197"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3379"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00088"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1695-x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1095185"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2012.09.008"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7571-6_1"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2538-3"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2010.12.002"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-6-37"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2016.0137"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500312"},{"key":"e_1_2_11_40_1","first-page":"274","article-title":"Efficacy and safety of Panax notoginseng Saponin therapy for acute Intracerebral hemorrhage, meta\u2010analysis, and mini review of potential mechanisms of action","volume":"5","author":"Xu D.","year":"2014","journal-title":"Frontiers in Neurology"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.05.020"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9309768"},{"issue":"36","key":"e_1_2_11_43_1","first-page":"2853","article-title":"Panax notoginseng saponin attenuates hypoxia\/reoxygenation\u2010induced oxidative stress in cortical neurons","volume":"7","author":"Yan C.","year":"2012","journal-title":"Neural Regeneration Research"},{"issue":"1","key":"e_1_2_11_44_1","first-page":"66","article-title":"Effect of hyperbaric oxygen on neurological recovery of neonatal rats following hypoxic\u2010ischemic brain damage and its underlying mechanism","volume":"6","author":"Yin X.","year":"2013","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14102"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666160119094646"},{"issue":"2","key":"e_1_2_11_47_1","first-page":"196","article-title":"The anti\u2010injury effect of breviscapine injection on the hypoxic ischemic brain damage of neonatal rats and the expression of Bcl\u20102 and Bax","volume":"27","author":"Zhang M. Y.","year":"2011","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2011.01379.x"},{"issue":"4","key":"e_1_2_11_49_1","first-page":"1225","article-title":"Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K\u2010AKT\u2010mTOR pathway in osteoarthritic chondrocytes","volume":"45","author":"Zhang Y.","year":"2020","journal-title":"International Journal of Molecular Medicine"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.15428","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:43:24Z","timestamp":1693197804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.15428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/ejn.15428"],"URL":"https:\/\/doi.org\/10.1111\/ejn.15428","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.15428\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15428\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15428\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15428\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15428\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"2021-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}