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By means of our long\u2010term follow\u2010up \u2018Vogel study\u2019, we aim to predict the pathological cognitive decline of a German cohort (mean age was 73.9\u2009\u00b1\u20091.55\u2009years at first visit) with three measurement time points within 6\u00a0years per participant. Especially in samples of the elderly and subjects with chronic or co\u2010morbid diseases, dropouts are one of the biggest problems of long\u2010term studies. In contrast to the large number of research articles conducted on the course of dementia, little research has been done on the completion of treatment. To ensure unbiased and reliable predictors of cognitive decline from study completers, our objective was to determine predictors of dropout. We conducted multivariate analyses of covariance and multinomial logistic regression analyses to compare and predict the subject's dropout behaviour at the second visit 3\u00a0years after baseline (full participation, partial participation and no participation\/dropout) with neuropsychiatric, cognitive, blood and lifestyle variables. Lower performance in declarative memory, attention and visual\u2013spatial processing predicted dropout rather than full participation. Lower performance in visual\u2013spatial processing predicted partial participation as opposed to full participation. Furthermore, lower performance in mini\u2010mental status examination predicted whether subjects dropped out or participated partially instead of full participation. Baseline cognitive parameters are associated with dropouts at follow\u2010up with a loss of impaired participants. We expect a bias into a healthier sample over time.<\/jats:p>","DOI":"10.1111\/ejn.15446","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T06:03:46Z","timestamp":1630994626000},"page":"5587-5600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Factors associated with dropout in the longitudinal Vogel study of cognitive decline"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-6268","authenticated-orcid":false,"given":"Sophia","family":"Haberstumpf","sequence":"first","affiliation":[{"name":"Center for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Leinweber","sequence":"additional","affiliation":[{"name":"Department of Psychotherapy Alexianer Psychiatric Hospital K\u00f6ln\u2010Porz  K\u00f6ln Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lauer","sequence":"additional","affiliation":[{"name":"Center for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Polak","sequence":"additional","affiliation":[{"name":"Center for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Deckert","sequence":"additional","affiliation":[{"name":"Center for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Center for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610218000017"},{"key":"e_1_2_11_3_1","unstructured":"Alzheimer's Disease International. 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