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The main aim of this work was to analyse how body weight loading influences PRM reflex threshold measured from several lower limb muscles in healthy participants. PRM reflex responses were evoked with 1\u2010ms rectangular monophasic pulses applied at an interval of 6\u00a0s via a self\u2010adhesive electrode (9\u2009\u00d7\u20095\u2009cm) at the T11\u2013T12 vertebral level. Surface electromyographic activity of lower limb muscles was recorded during four different conditions, one in decubitus supine (DS) and the other three involving standing at 100%, 50%, and 0% body weight loading (BW). PRM threshold intensity, peak\u2010to\u2010peak amplitude, and latency for each muscle were analysed in different conditions study. PRM reflex threshold increased with body weight unloading compared with DS, and the largest change was observed between DS and 0% BW for the proximal muscles and between DS and 50% BW for distal muscles. Peak\u2010to\u2010peak amplitude analysis showed only a significant mean decrease of 34.6% (SD 10.4,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.028) in TA and 53.6% (SD 15.1,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019) in GM muscles between DS and 50% BW. No significant differences were observed for PRM latency. This study has shown that sensorimotor networks can be activated with tSCS in various conditions of body weight unloading. Higher stimulus intensities are necessary to evoke reflex response during standing at 50% body weight loading. These results have practical implications for gait rehabilitation training programmes that include body weight support.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15448","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T04:36:09Z","timestamp":1631075769000},"page":"6575-6586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of posture and body weight loading on spinal posterior root reflex responses"],"prefix":"10.1111","volume":"54","author":[{"given":"\u00c1lvaro","family":"Meg\u00eda\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Biomechanical and Technical Aids Unit, National Hospital for Paraplegia SESCAM  Toledo Spain"},{"name":"Toledo Physiotherapy Research Group (GIFTO), Faculty of Physiotherapy and Nursing Castilla La Mancha University  Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7521-5087","authenticated-orcid":false,"given":"Diego","family":"Serrano\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Toledo Physiotherapy Research Group (GIFTO), Faculty of Physiotherapy and Nursing Castilla La Mancha University  Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Comino\u2010Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Neural Rehabilitation Group, Cajal Institute Spanish National Research Council (CSIC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio J.","family":"del\u2010Ama","sequence":"additional","affiliation":[{"name":"Biomechanical and Technical Aids Unit, National Hospital for Paraplegia SESCAM  Toledo Spain"},{"name":"Rey Juan Carlos University  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Moreno","sequence":"additional","affiliation":[{"name":"Neural Rehabilitation Group, Cajal Institute Spanish National Research Council (CSIC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Gil\u2010Agudo","sequence":"additional","affiliation":[{"name":"Biomechanical and Technical Aids Unit, National Hospital for Paraplegia SESCAM  Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Taylor","sequence":"additional","affiliation":[{"name":"Sensorimotor Function Group, National Hospital for Paraplegia SESCAM  Toledo Spain"},{"name":"Harris Manchester College University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"G\u00f3mez\u2010Soriano","sequence":"additional","affiliation":[{"name":"Toledo Physiotherapy Research Group (GIFTO), Faculty of Physiotherapy and Nursing Castilla La Mancha University  Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.11.011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-017-1687-x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-001-0926-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014897"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1688-13.2013"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00231664"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2010.12.008"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2011.01213.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147479"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.09.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1139\/y81-112"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33123-5"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00333"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6588"},{"issue":"1","key":"e_1_2_11_17_1","first-page":"000010151520134","article-title":"Effects of transcutaneous spinal cord stimulation on voluntary locomotor activity in an incomplete spinal cord injured individual","volume":"58","author":"Hofstoetter U. 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