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In the developing brain, COX\u20102 constitutively regulates the production of PGE2, which is important in neuronal development. However, abnormal COX\u20102\/PGE2 signalling has been linked to neurodevelopmental disorders including autism spectrum disorders (ASDs). We have previously demonstrated that COX\u20102\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2010KI mice show autism\u2010related behaviours including social deficits, repetitive behaviours and anxious behaviours. COX\u20102\u2010deficient mice also have deficits in pathways involved in synaptic transmission and dendritic spine formation. In this study, we use a Golgi\u2013COX staining method to examine sex\u2010dependent differences in dendritic and dendritic spine morphology in neurons of COX\u20102\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2010KI mice cerebellum compared with wild\u2010type (WT) matched controls at postnatal day 25 (P25). We show that COX\u20102\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2010KI mice have increased dendritic arborization closer to the cell soma and increased dendritic looping. We also observed a sex\u2010dependent effect of the COX\u20102\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2010KI on dendritic thickness, dendritic spine density, dendritic spine morphology, and the expression of \u03b2\u2010actin and the actin\u2010binding protein spinophilin. Our findings show that changes in COX\u20102\/PGE2 signalling lead to impaired morphology of dendrites and dendritic spines in a sex\u2010dependant manner and may contribute the pathology of the cerebellum seen in individuals with ASD. This study provides further evidence that the COX\u20102\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2010KI mouse model can be used to study a subset of ASD pathologies.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15454","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T14:38:15Z","timestamp":1631457495000},"page":"6355-6373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Abnormal dendritic morphology in the cerebellum of cyclooxygenase\u20102\n                    <sup>\u2212<\/sup>\n                    knockin mice"],"prefix":"10.1111","volume":"54","author":[{"given":"Ashby","family":"Kissoondoyal","sequence":"first","affiliation":[{"name":"School of Kinesiology and Health Science York University  Toronto Ontario Canada"},{"name":"Neuroscience Graduate Diploma Program York University  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravneet","family":"Rai\u2010Bhogal","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Diploma Program York University  Toronto Ontario Canada"},{"name":"Department of Biology York University  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-4195","authenticated-orcid":false,"given":"Dorota A.","family":"Crawford","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Health Science York University  Toronto Ontario Canada"},{"name":"Neuroscience Graduate Diploma Program York University  Toronto Ontario Canada"},{"name":"Department of Biology York University  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00328-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-19-08586.2002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.9.4002"},{"issue":"6","key":"e_1_2_11_5_1","first-page":"1987","article-title":"Acetaminophen use in pregnancy and neurodevelopment: Attention function and autism spectrum symptoms","volume":"45","author":"Avella\u2010Garcia C. 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