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Little is known about the underlying brain mechanisms. We have recently shown, in mice, that the post\u2010traumatic stress disorder\u2010like phenotype is characterised by the increase and decrease in total dendritic number and length in the prelimbic and infralimbic areas of the medial prefrontal cortex, respectively. Here, we examined whether repeated ethanol exposure would exacerbate these changes and whether this would be associated with difficulty to extinguish passive avoidance behaviour, as an indicator of treatment resistance. We also analysed whether other known trauma\u2010associated changes, like increased or decreased corticosterone and decreased brain\u2010derived neurotrophic factor levels, would also be exacerbated. Male mice underwent trauma exposure (1.5\u2010mA footshock), followed, 8\u2009days later, by a conditioned place preference training with ethanol. Tests for fear sensitization, passive avoidance, anxiety\u2010like behaviour, extinction acquisition and relapse susceptibility were used to assess behaviour changes. Plasma corticosterone and brain\u2010derived neurotrophic factor levels and prefrontal dendritic changes were subsequently measured. Trauma\u2010susceptible mice exposed to ethanol acquired a strong place preference and behaved differently from those not exposed to ethanol, with delayed avoidance extinction and higher avoidance relapse vulnerability. Ethanol potentiated trauma\u2010associated dendritic changes in the prelimbic area and suppressed trauma\u2010associated dendritic changes in the infralimbic area. However, ethanol had no effect on trauma\u2010induced increased corticosterone and decreased brain\u2010derived neurotrophic factor levels. These data suggest that the modification of prefrontal trauma\u2010related changes, due to alcohol use, can characterise, and probably support, treatment\u2010resistant post\u2010traumatic stress disorder.<\/jats:p>","DOI":"10.1111\/ejn.15499","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T19:33:03Z","timestamp":1634758383000},"page":"7710-7732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Repeated ethanol exposure following avoidance conditioning impairs avoidance extinction and modifies conditioning\u2010associated prefrontal dendritic changes in a mouse model of post\u2010traumatic stress disorder"],"prefix":"10.1111","volume":"54","author":[{"given":"Asmae","family":"Lguensat","sequence":"first","affiliation":[{"name":"Laboratoire de Pharmacologie, Neurobiologie, Anthropologie et Environnement Universit\u00e9 Cadi Ayyad  Marrakesh Morocco"},{"name":"Centre National de la Recherche Scientifique, Institut de Neurosciences de la Timone Aix Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zineb","family":"Boudjafad","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie, Neurobiologie, Anthropologie et Environnement Universit\u00e9 Cadi Ayyad  Marrakesh Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Giorla","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Institut de Neurosciences de la Timone Aix Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bennis","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie, Neurobiologie, Anthropologie et Environnement Universit\u00e9 Cadi Ayyad  Marrakesh Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4368-652X","authenticated-orcid":false,"given":"Christelle","family":"Baunez","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Institut de Neurosciences de la Timone Aix Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2780-2671","authenticated-orcid":false,"given":"Ren\u00e9","family":"Garcia","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Institut de Neurosciences de la Timone Aix Marseille Universit\u00e9  Marseille France"},{"name":"Graduate School of Life and Health Sciences Universit\u00e9 C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"Ba\u2010M'hamed","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie, Neurobiologie, Anthropologie et Environnement Universit\u00e9 Cadi Ayyad  Marrakesh Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-020-00303-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao1157"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12503"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-019-05408-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","unstructured":"Baker T. 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