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The aim of this study was to investigate sensorimotor interactions between the face and hand using an afferent inhibition transcranial magnetic stimulation protocol in which the motor evoked potential elicited by the magnetic pulse is inhibited when it is preceded by an afferent stimulus. We hypothesized that if face and hand representations in the sensorimotor cortex are functionally coupled, then electrocutaneous stimulation of the face would inhibit hand muscle motor responses. In two separate experiments, we delivered an electrocutaneous stimulus to either the skin over the right upper lip (Experiment 1) or right cheek (Experiment 2) and recorded muscular activity from the right first dorsal interosseous. Both lip and cheek stimulation inhibited right first dorsal interosseous motor evoked potentials. To investigate the specificity of this effect, we conducted two additional experiments in which electrocutaneous stimulation was applied to either the right forearm (Experiment 3) or right upper arm (Experiment 4). Forearm and upper arm stimulation also significantly inhibited the right first dorsal interosseous motor evoked potentials, but this inhibition was less robust than the inhibition associated with face stimulation. These findings provide the first evidence for face\u2010to\u2010hand afferent inhibition.<\/jats:p>","DOI":"10.1111\/ejn.15536","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T01:37:08Z","timestamp":1637285828000},"page":"189-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Face\u2013hand sensorimotor interactions revealed by afferent inhibition"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9609-961X","authenticated-orcid":false,"given":"Bia Lima","family":"Ramalho","sequence":"first","affiliation":[{"name":"IMPACT and Trajectoires Teams, INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center (CRNL)  Lyon France"},{"name":"University UCBL Lyon 1, University of Lyon  Lyon France"},{"name":"Laboratory of Neurobiology II, Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro  Rio de Janeiro 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