{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:43:36Z","timestamp":1772160216233,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18K17244"],"award-info":[{"award-number":["18K17244"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is accumulating evidence that nasal obstruction induces high\u2010level brain dysfunction, including memory and learning deficits. We previously demonstrated that unilateral nasal obstruction (UNO) during the growth period increases the expression of brain\u2010derived neurotrophic factor (BDNF). The expression of BDNF is regulated by the Wnt\/\u03b2\u2010Catenin pathway, which is linked to neuronal differentiation, proliferation, and maintenance. However, little is known about whether Wnt3a protein expression could be an index for modulations analyses in the Wnt\/\u03b2\u2010Catenin pathway caused by UNO during the growth period. This study aimed to investigate the effects of UNO during the growth period on the Wnt\/\u03b2\u2010Catenin pathway in the hippocampus using combined behavioural, biochemical, and histological approaches. Male BALB\/C mice were randomly divided into the control (CONT;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096) and experimental (UNO;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096) groups. Blood oxygen saturation (SpO\n                    <jats:sub>2<\/jats:sub>\n                    ) levels were measured, and a passive avoidance test was performed in mice aged 15\u2009weeks. Brain tissues were subjected to immunohistochemistry, real\u2010time reverse transcription\u2010polymerase chain reaction, and western blot analysis. Compared with control mice, UNO mice had lower SpO\n                    <jats:sub>2<\/jats:sub>\n                    levels and exhibited memory\/learning impairments during behavioural testing. Moreover, Wnt3a protein, BDNF mRNA, and tyrosine kinase receptor B (TrkB) mRNA expression levels were significantly lower in the hippocampus in the UNO group than in the CONT group. Our findings suggested that UNO during the growth period appeared to modulate the hippocampal Wnt\/\u03b2\u2010catenin pathway and BDNF production in association with TrkB mRNA reduction, thereby resulting in memory and learning impairments.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15547","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T05:09:50Z","timestamp":1638162590000},"page":"5-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nasal obstruction during the growth period modulates the Wnt\/\u03b2\u2010catenin pathway and brain\u2010derived neurotrophic factor production in association with tyrosine kinase receptor B mRNA reduction in mouse hippocampus"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3639-9589","authenticated-orcid":false,"given":"Hideyuki","family":"Ishidori","sequence":"first","affiliation":[{"name":"Department of Orthodontic Science, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU)  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemasa","family":"Okihara","sequence":"additional","affiliation":[{"name":"Department of Orthodontic Science, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU)  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Orthodontic Science, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University (TMDU)  Tokyo 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