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Microstructural alterations have been reported in DLB at the dementia stage, but no study to date was conducted in prodromal patients. Here, quantitative MRI data were collected from 46 DLB prodromal patients and 20 healthy elderly subjects, who also underwent a detailed clinical examination including the Mayo Clinic Fluctuation Scale. We conducted voxel\u2010wise between\u2010group comparisons in diffusion tensor imaging (DTI) metrics and in R2* mapping, along with a multivariate analysis combining the two modalities. We highlighted multiple grey matter and white matter microstructural changes in DLB patients at the prodromal stage, compared to control subjects. Our multivariate analysis identified three distinct regional patterns of DTI and R2* changes (anterior, anteromedial, posterior) in DLB patients, that could reflect different neuropathological processes across brain regions. We also observed an association between R2* alterations in the thalamus, and the severity of fluctuations, in the DLB group. These preliminary findings are promising and require future investigations to better understand the biological underpinnings of microstructural alterations.<\/jats:p>","DOI":"10.1111\/ejn.15558","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:55:37Z","timestamp":1639097737000},"page":"611-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Microstructural changes in prodromal dementia with Lewy bodies compared to normal ageing: Multiparametric quantitative MRI evidences"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-6725","authenticated-orcid":false,"given":"El\u00e9na","family":"Chabran","sequence":"first","affiliation":[{"name":"ICube Laboratory UMR 7357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS Team and IRIS Plateform University of Strasbourg and CNRS  Strasbourg 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