{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:09:24Z","timestamp":1791288564864,"version":"4.3.0"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007067","name":"Kempestiftelserna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007757","name":"Agencia Canaria de Investigaci\u00f3n, Innovaci\u00f3n y Sociedad de la Informaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007757","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Amyotrophic lateral sclerosis (ALS) is a lethal and incurable neurodegenerative disease due to the loss of upper and lower motor neurons, which leads to muscle weakness, atrophy, and paralysis. Sigma\u20101 receptor (\n                    <jats:italic>\u03c3<\/jats:italic>\n                    \u20101R) is a ligand\u2010operated protein that exhibits pro\u2010survival and anti\u2010apoptotic properties. In addition, mutations in its codifying gene are linked to development of juvenile ALS pointing to an important role in ALS. Here, we investigated the disease\u2010modifying effects of pridopidine, a\n                    <jats:italic>\u03c3<\/jats:italic>\n                    \u20101R agonist, using a delayed onset SOD1 G93A mouse model of ALS. Mice were administered a continuous release of pridopidine (3.0\u2009mg\/kg\/day) for 4 weeks starting before the appearance of any sign of muscle weakness. Mice were monitored weekly and several behavioural tests were used to evaluate muscle strength, motor coordination and gait patterns. Pridopidine\u2010treated SOD1 G93A mice showed genotype\u2010specific effects with the prevention of cachexia. In addition, these effects exhibited significant improvement of motor behaviour 5 weeks after treatment ended. However, the survival of the animals was not extended. In summary, these results show that pridopidine can modify the disease phenotype of ALS\u2010associated cachexia and motor deficits in a SOD1 G93A mouse model.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15608","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:29:50Z","timestamp":1643142590000},"page":"1356-1372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Pridopidine modifies disease phenotype in a SOD1 mouse model of amyotrophic lateral sclerosis"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3706-1320","authenticated-orcid":false,"given":"H\u00e9ctor M.","family":"Est\u00e9vez\u2010Silva","sequence":"first","affiliation":[{"name":"Department of Integrative Medical Biology Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Instituto de Tecnolog\u00edas Biom\u00e9dicas (ITB) Universidad de La Laguna Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-9864","authenticated-orcid":false,"given":"Tom\u00e1s","family":"Mediavilla","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Biology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-7675","authenticated-orcid":false,"given":"Bruno Lima","family":"Giacobbo","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Biology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-8500","authenticated-orcid":false,"given":"Xijia","family":"Liu","sequence":"additional","affiliation":[{"name":"Ume\u00e5 School of Business, Economics and Statistics Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9194-9905","authenticated-orcid":false,"given":"Fahad R.","family":"Sultan","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Biology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4618-7267","authenticated-orcid":false,"given":"Daniel J.","family":"Marcellino","sequence":"additional","affiliation":[{"name":"Department of Integrative Medical Biology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.007237"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.07.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22534"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.28.1_supplement.578.3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq338"},{"issue":"1","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/9780470942390.mo110165","article-title":"Assessment of motor coordination and balance in mice using the Rotarod, elevated bridge, and footprint tests","volume":"2","author":"Brooks S. 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