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Symptoms associated with cognitive impairment and dementia in PD may relate to direct structural changes to the corpus callosum via primary white matter pathology or as a secondary outcome due to the degeneration of cortical regions. Using magnetic resonance imaging, the corpus callosum can be investigated at the midsagittal plane, where it converges to a contiguous mass and is not intertwined with other tracts. The objective of this project was thus twofold: First, we investigated possible changes in the thickness of the midsagittal callosum and cortex in patients with PD with varying levels of cognitive impairment; and secondly, we investigated the relationship between the thickness of the midsagittal corpus callosum and the thickness of the cortex. Study participants included cognitively unimpaired PD participants (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200935), PD participants with mild cognitive impairment (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200922), PD participants with dementia (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200917) and healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200927). We found thinning of the callosum in PD\u2010related dementia compared with PD\u2010related mild cognitive impairment and cognitively unimpaired PD participants. Regression analyses found thickness of the left medial orbitofrontal cortex to be positively correlated with thickness of the anterior callosum in PD\u2010related mild cognitive impairment. This study suggests that a midsagittal thickness model can uncover changes to the corpus callosum in PD\u2010related dementia, which occur in line with changes to the cortex in this advanced disease stage.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15640","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:23:45Z","timestamp":1646958225000},"page":"1859-1872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Midsagittal corpus callosal thickness and cognitive impairment in Parkinson's disease"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0589-638X","authenticated-orcid":false,"given":"Conor","family":"Owens\u2010Walton","sequence":"first","affiliation":[{"name":"Research Centre for the Neurosciences of Ageing, Academic Unit of Psychiatry and Addiction Medicine, School of Clinical Medicine, Medical School Australian National University  Canberra ACT Australia"},{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Neuroinformatics Institute, Keck School of Medicine University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Adamson","sequence":"additional","affiliation":[{"name":"Developmental Imaging Murdoch Children's Research Institute  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Walterfang","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Unit, Royal Melbourne Hospital, Melbourne Neuropsychiatry Centre University of Melbourne and Melbourne Health  Melbourne Victoria Australia"},{"name":"Florey Institute of Neurosciences and Mental Health University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Hall","sequence":"additional","affiliation":[{"name":"Memory Clinic Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"van Westen","sequence":"additional","affiliation":[{"name":"Centre for Medical Imaging and Physiology Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Diagnostic Radiology, Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[{"name":"Memory Clinic Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Department of Clinical Sciences Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marnie","family":"Shaw","sequence":"additional","affiliation":[{"name":"College of Engineering and Computer Science The Australian National University  Canberra ACT Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C. 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