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Therefore, the aim of the present work was to investigate in an experimental model of adolescent animals whether noise exposure and intermittent ethanol intake, when present individually or sequentially, might be able to modify different behaviours. Adolescent Wistar rats of both sexes were subjected to voluntary intermittent ethanol intake for 1\u00a0week followed by exposure to noise for 2\u00a0h and tested in a battery of behavioural tasks. Data show that males exposed to noise experienced a deficit in associative memory (AM), increase in anxiety\u2010like behaviours (ALB) and altered reaction to novelty (RN) when compared with sham animals, whereas females also showed an increase in risk assessment behaviours (RABs) and a decrease in exploratory activity (EA). In contrast, ethanol intake induced an increase in RAB and RN in males and females, whereas females also showed a deficit in AM and EA as well as an increase in ALB. When ethanol was ingested before noise exposure, most parameters were counteracted both in male and females, but differed among sexes. In consequence, it could be hypothesized that an environmental acute stressor like noise might trigger a behavioural counteracting induced by a previous repeated exposure to a chemical agent such as ethanol, leading to a compensation of a non\u2010adaptive behaviour and reaching a better adjustment to the environment.<\/jats:p>","DOI":"10.1111\/ejn.15657","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T03:54:03Z","timestamp":1648439643000},"page":"1756-1773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Behavioural alterations induced by intermittent ethanol intake and noise exposure in adolescent rats"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-6151","authenticated-orcid":false,"given":"Gustavo Ezequiel","family":"Buj\u00e1n","sequence":"first","affiliation":[{"name":"1\u00aa C\u00e1tedra de Farmacolog\u00eda, Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"D'Alessio","sequence":"additional","affiliation":[{"name":"1\u00aa C\u00e1tedra de Farmacolog\u00eda, Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Instituto de Biolog\u00eda Celular y Neurociencias (IBCN, UBA\u2010CONICET), Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor Alejandro","family":"Serra","sequence":"additional","affiliation":[{"name":"1\u00aa C\u00e1tedra de Farmacolog\u00eda, Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia Jazm\u00edn","family":"Molina","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires. 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