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Using genetic fate mapping associated with the immunollabeling\u2010enabled three\u2010dimensional imaging of solvent\u2010cleared organs (iDISCO) clearing method we identified and counted a selective population of neocortical and hippocampal pyramidal neurons in the in utero valproate (VPA) mouse model of autism. We report that 1\u2009day before birth, the number of pyramidal neurons born at E14.5 in the neocortex and hippocampus of VPA mice is smaller than in age\u2010matched controls. VPA also induced a reduction of the neocortical\u2014but not hippocampal\u2014volume 1\u2009day before birth. Interestingly, VPA mice present an increase in both neocortical and hippocampal volumes 2\u00a0days after birth compared with controls. These results suggest that the VPA\u2010exposed hippocampus and neocortex differ substantially from controls during the highly complex perinatal period, and specially 1\u2009day before birth, reflecting the early pathogenesis of ASD.<\/jats:p>","DOI":"10.1111\/ejn.15724","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T21:38:19Z","timestamp":1653946699000},"page":"3875-3888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prenatal reduction of E14.5 embryonically fate\u2010mapped pyramidal neurons in a mouse model of autism"],"prefix":"10.1111","volume":"56","author":[{"given":"Amandine","family":"Dufour","sequence":"first","affiliation":[{"name":"Fundamental Research Department Neurochlore  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Dumon","sequence":"additional","affiliation":[{"name":"Fundamental Research Department 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