{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:43:39Z","timestamp":1772160219246,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16am0101012j0005"],"award-info":[{"award-number":["16am0101012j0005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H01586"],"award-info":[{"award-number":["JP17H01586"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K21592"],"award-info":[{"award-number":["JP19K21592"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K16511"],"award-info":[{"award-number":["JP20K16511"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H03024"],"award-info":[{"award-number":["JP21H03024"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The intermittent cold stress\u2010induced generalized pain response mimics the pathophysiological and pharmacotherapeutic features reported for fibromyalgia patients, including the presence of chronic generalized pain and female dominance. In addition, the intermittent cold stress\u2010induced generalized pain is abolished in lysophosphatidic acid receptor type\u20101 knockout mice, as reported in many cases of neuropathic pain models. This study aimed to identify the brain loci involved in the intermittent cold stress generalized pain response and test their dependence on the lysophosphatidic acid receptor type\u20101. Positron emission tomography analyses using 2\u2010deoxy\u20102\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]fluoro\u2010\n                    <jats:sc>d<\/jats:sc>\n                    \u2010glucose in the presence of a pain stimulus showed that intermittent cold stress causes a significant increase in uptake in the ipsilateral regions, including the salience networking\u2010related anterior cingulate cortex and insular cortex and the cognition\u2010related hippocampus. A significant decrease was observed in the default mode network\u2010related posterior cingulate cortex. Almost these intermittent cold stress\u2010induced changes were abolished in lysophosphatidic acid receptor type\u20101 knockout mice. There results suggest that the intermittent cold stress\u2010induced generalized pain response is mediated by the lysophosphatidic acid receptor type\u20101 in specific brain loci related to salience networking and cognition, which may lead to further developments in the treatment of fibromyalgia.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15729","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T13:13:49Z","timestamp":1654521229000},"page":"4224-4233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lysophosphatidic acid receptor type\u20101 mediates brain activation in micro\u2010positron emission tomography analysis in a fibromyalgia\u2010like mouse model"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-9813","authenticated-orcid":false,"given":"Hiroyuki","family":"Neyama","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutic Innovation Nagasaki University Institute of Biomedical Sciences  Nagasaki Japan"},{"name":"Laboratory for Biofunction Dynamics Imaging RIKEN Center for Biosystems Dynamics Research  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Nishiyori","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic Innovation Nagasaki University Institute of Biomedical Sciences  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilong","family":"Cui","sequence":"additional","affiliation":[{"name":"Laboratory for Biofunction Dynamics Imaging RIKEN Center for Biosystems Dynamics Research  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2623-5599","authenticated-orcid":false,"given":"Yasuyoshi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Laboratory for Pathophysiological and Health Science RIKEN Center for Biosystems Dynamics Research  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-0137","authenticated-orcid":false,"given":"Hiroshi","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic Innovation Nagasaki University Institute of Biomedical Sciences  Nagasaki Japan"},{"name":"Laboratory for the Study of Pain Research Institute for Production Development  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.07.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001332"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.01.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5564-10.2011"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3266"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.24.13384"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.047"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4402"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002134"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.09.006"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00392-5"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001252"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1161-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101678R"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1060"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000606"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000318"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.04.005"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-08-03043.1998"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408576102"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.08.016"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0262-0"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66930-w"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.26599\/BSA.2019.9050025"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107896"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2016.01.002"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.222414"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.05.024"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.120.265942"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.262642"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.01.080"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-69"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-4-52"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.11.047"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.02.437"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13662"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093535"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.006"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200101)24:1<37::AID-MUS4>3.0.CO;2-8"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.12.018"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.10.005"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10188"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00146"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-10-71"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000813"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b19-00535"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2020.101079"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.600166"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynpai.2017.04.002"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081906"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001316"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynpai.2018.07.001"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00232"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.06.009"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.85202"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.15729","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T21:29:39Z","timestamp":1692739779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.15729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,10]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/ejn.15729"],"URL":"https:\/\/doi.org\/10.1111\/ejn.15729","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.15729\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15729\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15729\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15729\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15729\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15729\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15729\/v2\/review1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,10]]},"assertion":[{"value":"2021-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}