{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:03:20Z","timestamp":1791849800419,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Epilepsy is increasing, being more common in older adults, with more than 20% of late\u2010onset cases with unknown aetiology (LOEU). Although epilepsy was associated with cognitive impairment, few studies evaluated the trajectories of cognitive decline in patients with LOEU. The present study aimed at assessing biomarkers of Alzheimer's disease (AD) in patients with LOEU and evaluating their cognitive performance for 12\u2009months. For this study, 55 patients diagnosed with LOEU and 21 controls were included. Participants underwent cognitive evaluation and cerebrospinal fluid (CSF) biomarker analysis (\u00df\u2010amyloid\n                    <jats:sub>42<\/jats:sub>\n                    , tau proteins) before starting anti\u2010seizure medication and then repeated the cognitive evaluation at the 12\u2010month follow\u2010up. A subgroup of LOEU patients and controls also performed\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose positron emission tomography (\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG PET) before starting anti\u2010seizure medication. At baseline, LOEU patients showed lower Mini\u2010Mental State Examination (MMSE) score, worse cognitive performance in several domains, lower \u03b2\u2010amyloid\n                    <jats:sub>42<\/jats:sub>\n                    and higher tau proteins CSF levels than controls. Significantly reduced glucose consumption was observed in the right posterior cingulate cortex and left praecuneus areas in LOEU patients than controls, and this finding correlated with memory impairment. In the longitudinal analysis, a significant decrease in MMSE and an increase in verbal fluency scores were found in LOEU patients. These findings evidence that LOEU patients have a significant cognitive impairment, and alteration of cerebral glucose consumption and CSF AD biomarkers than controls. Moreover, they showed a progressive global cognitive decline at follow\u2010up, although verbal fluency was preserved. Further studies are needed to better understand the pathophysiological aspects of LOEU and its association with AD.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15734","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T10:44:50Z","timestamp":1654771490000},"page":"5384-5396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Cognitive functioning, cerebrospinal fluid Alzheimer's disease biomarkers and cerebral glucose metabolism in late\u2010onset epilepsy of unknown aetiology: A prospective study"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7005-2805","authenticated-orcid":false,"given":"Mariana","family":"Fernandes","sequence":"first","affiliation":[{"name":"Epilepsy Centre, Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Aluisantonio","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaminia","family":"Franchini","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Chiaravalloti","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention University of Rome \u201cTor Vergata\u201d  Rome Italy"},{"name":"IRCCS Neuromed  Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Izzi","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Di Santo","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orazio","family":"Schillaci","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention University of Rome \u201cTor Vergata\u201d  Rome Italy"},{"name":"IRCCS Neuromed  Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Biagio","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"},{"name":"IRCCS Fondazione Santa Lucia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Placidi","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-1332","authenticated-orcid":false,"given":"Claudio","family":"Liguori","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Neurology Unit, Department of Systems Medicine University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03043.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493484"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsp053"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100720200003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000117297"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04379-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2005.07.016"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.08.025"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy162"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.09.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-73273-0_27"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.15967"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.107839"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.12.023"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20730"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb02586.x"},{"key":"e_1_2_10_19_1","unstructured":"He W. Goodkind D. &Kowal P.(2016).An Aging World: 2015 International Population Reports Aging."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.02.017"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.12.016"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2006.06.018"},{"key":"e_1_2_10_23_1","unstructured":"IBM. (2020).SPSS \u2010 Statistical Package for Social Sciences."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1997)5:4<238::AID-HBM6>3.0.CO;2-4"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-009-8076-z"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-016-3417-2"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106592"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.01.003"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191124"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111434"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.808"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jamia.2001.0080401"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1995.1012"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.130518"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00199"},{"key":"e_1_2_10_37_1","first-page":"206","article-title":"test de copie dune figure complexe [A test regarding a complex figure]","volume":"30","author":"Osterreith P. A.","year":"1944","journal-title":"Archiv f\u00fcr Psychologie"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.5_suppl_2.S24"},{"key":"e_1_2_10_39_1","volume-title":"LExamin Clinique En Psychologie","author":"Rey A.","year":"1964"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.07.028"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13709"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy022"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12218"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2013.06.005"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12962"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12260"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.15734","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:59:58Z","timestamp":1692640798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.15734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,18]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/ejn.15734"],"URL":"https:\/\/doi.org\/10.1111\/ejn.15734","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.15734\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15734\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15734\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15734\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15734\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15734\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15734\/v3\/response1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,18]]},"assertion":[{"value":"2021-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}