{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:43:43Z","timestamp":1772160223332,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["313466\/2018\u20101"],"award-info":[{"award-number":["313466\/2018\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To compare cell adhesion molecules levels in cerebrospinal fluid (CSF) between Zika virus (ZIKV)\u2010exposed neonates with\/without microcephaly (cases) and controls, 16 neonates (cases), 8 (50%) with and 8 (50%) without microcephaly, who underwent lumbar puncture (LP) during the ZIKV epidemic (2015\u20132016) were included. All mothers reported ZIKV clinical symptoms during gestation, all neonates presented with congenital infection findings, and other congenital infections were ruled out. Fourteen control neonates underwent LP in the same laboratory (2017\u20132018). Five cell adhesion proteins were measured in the CSF using mass spectrometry. Neurexin\u20101 (3.50 [2.00\u20134.00] vs. 7.5 [5.00\u201310.25],\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001), neurexin\u20103 (0.00 [0.00\u20130.00] vs. 3.00 [1.50\u20134.00],\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001) and neural cell adhesion molecule 2 (NCAM2) (0.00 [0.00\u20130.75] vs. 1.00 [1.00\u20132.00],\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001) were significantly lower in microcephalic and non\u2010microcephalic cases than in controls. When these two sub\u2010groups of prenatally ZIKA\u2010exposed children were compared to controls separately, the same results were found. When cases with and without microcephaly were compared, no difference was found. Neurexin\u20103 (18.8% vs. 78.6%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001) and NCAM2 (25.0% vs. 85.7%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001) were less frequently found among the cases. A positive correlation was found between cephalic perimeter and levels of these two proteins. Neurexin\u20102 and neurexin\u20102b presented no significant differences. Levels of three cell adhesion proteins were significantly lower in CSF of neonates exposed to ZIKV before birth than in controls, irrespective of presence of congenital microcephaly. Moreover, the smaller the cephalic perimeter, the lower CSF cell adhesion protein levels. These findings suggest that low CSF levels of neurexin\u20101, neurexin\u20103 and NCAM2 may reflect the effects of ZIKV on foetal brain development.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15851","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T07:19:18Z","timestamp":1666855158000},"page":"6258-6268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell adhesion proteins in the cerebrospinal fluid of neonates prenatally exposed to Zika virus: A case\u2013control study"],"prefix":"10.1111","volume":"56","author":[{"given":"Clara L.","family":"Ramos","sequence":"first","affiliation":[{"name":"Bahiana Foundation for Science Development Bahiana School of Medicine  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo C.","family":"Nascimento\u2010Carvalho","sequence":"additional","affiliation":[{"name":"Bahiana Foundation for Science Development Bahiana School of Medicine  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo C.","family":"Nascimento\u2010Carvalho","sequence":"additional","affiliation":[{"name":"Bahiana Foundation for Science Development Bahiana School of Medicine  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-994X","authenticated-orcid":false,"given":"Martijn M.","family":"VanDuijn","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC  Rotterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana\u2010Luisa","family":"Vilas\u2010Boas","sequence":"additional","affiliation":[{"name":"Bahiana Foundation for Science Development Bahiana School of Medicine  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ot\u00e1vio A.","family":"Moreno\u2010Carvalho","sequence":"additional","affiliation":[{"name":"Cerebrospinal Fluid Laboratory Jos\u00e9 Silveira Foundation  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas P.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research, LAPEC Gon\u00e7alo Moniz Institute  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lona","family":"Zeneyedpour","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC  Rotterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerben","family":"Ferwerda","sequence":"additional","affiliation":[{"name":"Section of Paediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud Centre for Infectious Diseases Radboud University Medical Center  Nijmegen Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"de Groot","sequence":"additional","affiliation":[{"name":"Section of Paediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud Centre for Infectious Diseases Radboud University Medical Center  Nijmegen Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo M.","family":"Luider","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus MC  Rotterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3942-2492","authenticated-orcid":false,"given":"Cristiana M.","family":"Nascimento\u2010Carvalho","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Federal University of Bahia School of Medicine  Salvador 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