{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:07:44Z","timestamp":1775056064743,"version":"3.50.1"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA13023"],"award-info":[{"award-number":["R01AA13023"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fetal alcohol spectrum disorder (FASD) is one of the most common causes of mental disabilities in the world with a prevalence of 1%\u20136% of all births. Sensory processing deficits and cognitive problems are a major feature in this condition. Because developmental alcohol exposure can impair neuronal plasticity, and neuronal plasticity is crucial for the establishment of neuronal circuits in sensory areas, we predicted that exposure to alcohol during the third trimester equivalent of human gestation would disrupt the development of multisensory integration (MSI) in the rostral portion of the posterior parietal cortex (PPr), an integrative visual\u2013tactile area. We conducted in vivo electrophysiology in 17 ferrets from four groups (saline\/alcohol; infancy\/adolescence). A total of 1157 neurons were recorded after visual, tactile and combined visual\u2013tactile stimulation. A multisensory (MS) enhancement or suppression is characterized by a significantly increased or decreased number of elicited spikes after combined visual\u2013tactile stimulation compared to the strongest unimodal (visual or tactile) response. At the neuronal level, those in infant animals were more prone to show MS suppression whereas adolescents were more prone to show MS enhancement. Although alcohol\u2010treated animals showed similar developmental changes between infancy and adolescence, they always \u2018lagged behind\u2019 controls showing more MS suppression and less enhancement. Our findings suggest that alcohol exposure during the last months of human gestation would stunt the development of MSI, which could underlie sensory problems seen in FASD.<\/jats:p>","DOI":"10.1111\/ejn.15907","type":"journal-article","created":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T05:58:52Z","timestamp":1673071132000},"page":"784-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of developmental alcohol exposure on cortical multisensory integration"],"prefix":"10.1111","volume":"57","author":[{"given":"Dongil","family":"Keum","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Pultorak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Alex","family":"Meredith","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0517-7756","authenticated-orcid":false,"given":"Alexandre E.","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Maryland School of Medicine  Baltimore Maryland 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