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Identification of autistic markers remains a top priority in achieving an early and effective ASD diagnosis. We have previously reported that prenatal exposure of hormones or diabetes triggers epigenetic changes and oxidative stress, resulting in gene suppression with autism\u2010like behaviours in offspring. Here, a potential biomarker for ASD diagnosis was established through gene analysis in peripheral blood mononuclear cells (PBMCs). The study from in vivo mouse showed that prenatal hormone exposure or maternal diabetes suppresses mRNA expression of estrogen\u2010related receptor \u03b1 (ERR\u03b1), superoxide dismutase 2 (SOD2), G protein\u2010coupled estrogen receptor (GPER) and retinoic acid\u2010related orphan receptor \u03b1 (RORA) in the brain as well as oxidative stress and mitochondrial dysfunction, subsequently triggering autism\u2010like behaviour in mouse offspring. Also, similar gene suppression was found in hematopoietic stem cells (HSCs) and PBMC, with inherited epigenetic changes being identified on the related promoters. The human case\u2013control study found that mRNA levels of ERR\u03b1, SOD2, GPER and RORA were significantly reduced in PBMC from ASD subjects (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u2009132) compared with typically developing (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u2009135) group. The receiver operating characteristic curve showed a .869\u2009\u00b1\u2009.021 of area under the curve for ASD subjects with 95% confidence interval of .829\u2013.909, together with 1.000 of sensitivity and .856 of specificity. In conclusion, the combined mRNA expression in PBMC based on prenatal factor exposure\u2010mediated gene suppression could be a potential biomarker for ASD diagnosis.\n                  <\/jats:p>","DOI":"10.1111\/ejn.15935","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T22:28:40Z","timestamp":1676413720000},"page":"1184-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prenatal exposure of diabetes and progestin\u2010mediated autistic biomarker in peripheral blood mononuclear cells"],"prefix":"10.1111","volume":"57","author":[{"given":"Yun","family":"Jiao","sequence":"first","affiliation":[{"name":"Hainan Women and Children's Medical Center  Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan Women and Children's Medical Center  Haikou 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