{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:22:44Z","timestamp":1787984564559,"version":"build-2784847793"},"reference-count":83,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013306","name":"National Institute of Science Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A healthy state of life suggests not only a disease\u2010free condition but also normal psychological functioning and behaviour. To maintain a healthy life, the duration of light exposure is a crucial factor. Perturbation of the standard light\u2013dark cycle (LD: 12\u2009h light\u201012\u2009h dark in mice) may result in brain, behavioural and physiological abnormalities. The current study determined the effects of 3 and 5\u00a0weeks of constant darkness (DD: 00\u2009h light\u201024\u2009h dark) on the behaviour, hormones, prefrontal cortex (PFC) and metabolome of male and female C57BL\/6\u00a0J mice. We also studied 3\u2009weeks of restoration in LD following 5\u2009weeks of DD exposure. The results revealed that 3\u2009weeks of DD affected male mice more than females, and 5\u2009weeks of DD had a comparable impact on behaviour, hormones and the PFC of male and female mice. After restoration in LD, the DD\u2010induced changes reverted to time\u2010matched LD conditions in male and female mice. Furthermore, metabolome analysis corroborated male and female mice's behavioural and molecular kinetics. The present study laid the foundation for understanding how DD affects behaviour and the PFC as a function of (a) time and (b) sex and described the roles of stress and sex hormones, cytokines, neurotrophins and metabolic pathways.<\/jats:p>","DOI":"10.1111\/ejn.15972","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:59:13Z","timestamp":1679533153000},"page":"1498-1515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of constant darkness on behaviour and physiology of male and female mice"],"prefix":"10.1111","volume":"57","author":[{"given":"Dhyanendra","family":"Singh","sequence":"first","affiliation":[{"name":"School of Biological Sciences National Institute of Science Education and Research (NISER), HBNI  Jatni Odisha India"},{"name":"Homi Bhabha National Institute Training School Complex, Anushaktinagar  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Pandey","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences National Institute of Science Education and Research (NISER), HBNI  Jatni Odisha India"},{"name":"Homi Bhabha National Institute Training School Complex, Anushaktinagar  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arindam","family":"Ghosh","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences National Institute of Science Education and Research (NISER), HBNI  Jatni Odisha India"},{"name":"Homi Bhabha National Institute Training School Complex, Anushaktinagar  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4927-7812","authenticated-orcid":false,"given":"Palok","family":"Aich","sequence":"additional","affiliation":[{"name":"School of Biological Sciences National Institute of Science Education and Research (NISER), HBNI  Jatni Odisha India"},{"name":"Homi Bhabha National Institute Training School Complex, Anushaktinagar  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3750307"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113638"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706257"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.96"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.05.012"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/scnp.2001.21837"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00430"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22566"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.06.004"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.07.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-014-9643-z"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-015-0035-9"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0802-06.2006"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.12.011"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000124930"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00056"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176368"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00127"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2019.100177"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-015-9608-x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00609"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703615105"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.123"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2005.04.005"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.05.016"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0685-9"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2013.0338"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36749"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2019-00053"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/jom-1984-840928"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1127\/anthranz\/62\/2004\/311"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00863"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368910X539065"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20131434"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1803645115"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2018.03.036"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.4236\/wjns.2016.63022"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.8.e17"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2006"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvs006"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1537-11.2011"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1426846"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2021.101136"},{"key":"e_1_2_12_45_1","first-page":"1","volume-title":"Palok Aich","author":"Mukhopadhyay S.","year":"2020"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TX00006B"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11092590"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126151"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajbr.v4i3.53888"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000211Y.0000000016"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150042"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2011.08.006"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30187"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi104"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00546-7"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11010045"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3791\/52434-v"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253899909001120"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600965113"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.104415"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243668"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7292540"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0269-19.2019"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00456"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.10.023"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5725-10.2011"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.05.028"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/351598"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.01.072"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.06.001"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-010-0699-3"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12179"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(97)00030-8"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2009.07.004"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2002.00798.x"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091488"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.11.032"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2019.11.007"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.10.070"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/24705470211029254"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi1410s34"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.12.002"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.131"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/lsa.2016.231"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.15972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:27:34Z","timestamp":1692678454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.15972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":83,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/ejn.15972"],"URL":"https:\/\/doi.org\/10.1111\/ejn.15972","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.15972\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.15972\/v2\/review1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]},"assertion":[{"value":"2022-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}