{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:31:46Z","timestamp":1787725906864,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ageing is accompanied by numerous changes within the sensory and motor components of the muscle spindle pathway. To further document these age\u2010related changes, this study compared the characteristics of the Hoffmann (H) reflex and M wave, evoked with several pulse durations, between young and old adults. The H\u2010reflex and M\u2010wave recruitment curves were recorded at rest in the flexor carpi radialis of 12 young (21\u201336\u2009years) and 12 older adults (62\u201380\u2009years). For each pulse duration (0.05, 0.2 and 1\u00a0ms), the maximal M\u2010wave (M\n                    <jats:sub>MAX<\/jats:sub>\n                    ) and H\u2010reflex (H\n                    <jats:sub>MAX<\/jats:sub>\n                    ) amplitude, the M\u2010wave amplitude associated with H\n                    <jats:sub>MAX<\/jats:sub>\n                    (M\n                    <jats:sub>Hmax<\/jats:sub>\n                    ) and the H\u2010reflex amplitude for a stimulus intensity evoking an M\u2010wave of 5% M\n                    <jats:sub>MAX<\/jats:sub>\n                    (H\n                    <jats:sub>M5%<\/jats:sub>\n                    ) were measured. The strength\u2010duration time constant and response threshold were estimated from the charge\/stimulus\u2010duration relation for the H reflex and M wave. Results indicate that varying pulse duration mainly induces a similar effect on H\u2010reflex and M\u2010wave recruitment curves between young and older adults. Regardless of pulse duration, old adults had lesser H\n                    <jats:sub>MAX<\/jats:sub>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.029) and H\n                    <jats:sub>M5%<\/jats:sub>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) but greater M\n                    <jats:sub>Hmax<\/jats:sub>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The H\u2010reflex and M\u2010wave response thresholds were greater in old than young adults (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), but the strength\u2010duration time constant was lesser in old than young adults for the H reflex (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.048) but not the M wave (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.21). These results suggest greater age\u2010related changes in the sensory than the motor component of the H\u2010reflex pathway, which may be indicative of a greater loss of sensory than motor axons or alterations of synapses between Ia afferents and motor neurones.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16000","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T04:55:00Z","timestamp":1682744100000},"page":"1803-1814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Age\u2010related changes in sensory and motor components of the Hoffmann\u2010reflex pathway of the flexor carpi radialis"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6589-0281","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Henry","sequence":"first","affiliation":[{"name":"Laboratory of Applied Biology, Research Unit in Applied Neurophysiology (LABNeuro), 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