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This study explored white matter plasticity in nonexpert healthy adults, based on stepwise balance training. Seventeen participants were included and performed a home\u2010based balance training program for 4\u00a0weeks (30\u2009min\/day, 3\u00a0days\/week). Before commencing training, they underwent a baseline diffusion tensor imaging scan. A second scan was acquired at the end of the 4\u2010week training. Lateralised balance load was applied on the right leg to contrast any lateralised effect on the white matter tracts. The balance function was assessed using the Community Balance &amp; Mobility Scale. We examined changes in the fractional anisotropy values of the tracts of interest between pre\u2010 and post\u2010training. After the 4\u2010week training, the fractional anisotropy values were enhanced in the right superior cerebellar peduncle, transverse pontine fibre, body of the corpus callosum, left fornix and left uncinate fasciculus. The Community Balance &amp; Mobility Scale\u00a0score improved after 4\u2010week training, but an association with changes in fractional anisotropy values cannot be evaluated due to the ceiling effect of the balance assessment tools. Balance training can strengthen the cerebro\u2010cerebellar and interhemispheric structural connections and induce microstructural changes in the limbic structures, including the fornix and uncinate fasciculus. The effect of a lateralised balance load could be projected to the specific white matter tracts in a lateralised manner.<\/jats:p>","DOI":"10.1111\/ejn.16005","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T03:15:00Z","timestamp":1682910900000},"page":"1789-1802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evidence of lateralised white matter plasticity: A longitudinal study of balance performance in nonexpert healthy adults"],"prefix":"10.1111","volume":"57","author":[{"given":"Sun","family":"Im","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Bucheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeehae","family":"Oh","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine  Seoul Republic of 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