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We used long\u2010term potentiation\u2010like plasticity of the visual evoked potential as an index of synaptic function in the cortex and hypothesized that plasticity at baseline would be negatively associated with future cortical thinning in healthy adults and in adults with bipolar disorder type II. Thirty\u2010two healthy adults and 15 adults with bipolar disorder type II underwent electroencephalography\u2010based measurement of visual evoked potential plasticity and 3T magnetic resonance imaging of the brain at baseline and a follow\u2010up brain scan on average 2.3\u2009years later. The relationships between visual evoked potential plasticity at baseline and longitudinal cortical thickness changes were examined using Freesurfer and the Permutation Analysis of Linear Models tool. The analyses showed a negative association between the plasticity of the N1 visual evoked potential amplitude at baseline and thinning rate in the medial and lateral parietal and medial occipital cortices in healthy adults and in the right medial occipital cortex in the total sample of healthy adults and adults with bipolar disorder type II, indicating greater thinning over time in subjects with less N1 plasticity (<jats:italic>p<\/jats:italic><jats:sub>FWER<\/jats:sub>\u2009&lt;\u2009.05). Although preliminary, the results indicate an association between visual evoked potential plasticity and the future rate of cortical thinning in healthy adults and in bipolar disorder type II, supporting the hypothesis that cortical thinning might be related to synaptic dysfunction.<\/jats:p>","DOI":"10.1111\/ejn.16038","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T05:18:31Z","timestamp":1683782311000},"page":"2824-2837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline long\u2010term potentiation\u2010like cortical plasticity is associated with longitudinal cortical thinning in healthy adults and in adults with bipolar disorder type II"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7057-6457","authenticated-orcid":false,"given":"Nathalia","family":"Zak","sequence":"first","affiliation":[{"name":"Norwegian Centre for Mental 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