{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:43:45Z","timestamp":1772160225923,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["1R21MH117636\u201001A1"],"award-info":[{"award-number":["1R21MH117636\u201001A1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006988","name":"John S. Dunn Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006988","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013379","name":"Instituto Mente e C\u00e9rebro - Neuroci\u00eancia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013379","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The present study aimed to evaluate if sepsis sensitizes behavioural and biochemical responses induced by m\u2010amphetamine. For this, Wistar rats were submitted to the cecal ligation and puncture. After 30\u2009days of cecal ligation and puncture procedure, the animals were submitted to a single intraperitoneal injection of saline or m\u2010amphetamine (.25, .50, or 1.0\u2009mg\/kg). Locomotor behaviour was assessed 2\u2009h after the administration. Interleukin (IL)\u20101\u03b2, IL\u20106, IL\u201010, tumour necrosis factor\u2010\u03b1, dopamine\u2010cAMP\u2010regulated phosphoprotein of 32,000\u2009kDa (DARPP\u201032) and neuronal calcium sensor (NCS\u20101) levels were evaluated in the frontal cortex, hippocampus and striatum. Also, brain\u2010derived neurotrophic factor (BDNF), neuronal growth factor and glial\u2010derived neurotrophic factor levels were assessed in the hippocampus. M\u2010amphetamine alone (.25 and 1.0\u2009mg\/kg) increased rats' locomotion and exploratory behaviour compared with the Sham\u2009+\u2009Sal. Animals from the cecal ligation and puncture\u2009+\u2009m\u2010amphetamine (.5 and\/or 1.0\u2009mg\/kg) group showed an increase in locomotion, exploratory and risk\u2010like behaviour when compared with the Sham\u2009+\u2009Saline group and with its respective Sham groups. Cecal ligation and puncture increased interleukin levels compared with the Sham\u2009+\u2009Sal. However, cecal ligation and puncture animals that received m\u2010amphetamine (1\u2009mg\/kg) increased even more, these inflammatory parameters compared with the Sham\u2009+\u2009Sal and the cecal ligation and puncture\u2009+\u2009saline group. M\u2010amphetamine at lower doses increased neurotrophic factors, but higher doses decreased these parameters in the brain of cecal ligation and puncture rats. M\u2010amphetamine dose\u2010dependently increased DARPP\u201032 and NCS\u20101 levels in cecal ligation and puncture rats in some structures. In conclusion, these results demonstrate that sepsis sensitizes behavioural amphetamine responses while inducing inflammatory and neurotrophic vulnerability in the cecal ligation and puncture model.<\/jats:p>","DOI":"10.1111\/ejn.16064","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T20:21:17Z","timestamp":1687638077000},"page":"1153-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sepsis sensitizes behavioural amphetamine responses while inducing inflammatory and neurotrophic vulnerability in the cecal ligation and puncture model"],"prefix":"10.1111","volume":"59","author":[{"given":"Samira S.","family":"Valvassori","sequence":"first","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences University of Southern Santa Catarina (UNESC)  Crici\u00fama Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-2576","authenticated-orcid":false,"given":"Taise","family":"Possamai\u2010Della","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences University of Southern Santa Catarina (UNESC)  Crici\u00fama Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge M.","family":"Aguiar\u2010Geraldo","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences University of Southern Santa Catarina (UNESC)  Crici\u00fama Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00f4mulo Goronci","family":"Sant'Ana","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences University of Southern Santa Catarina (UNESC)  Crici\u00fama Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo C.","family":"Dal\u2010Pont","sequence":"additional","affiliation":[{"name":"Translational Health Research Laboratory Alto Vale do Rio do Peixe University  Ca\u00e7ador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna","family":"Pescador","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences University of Southern Santa Catarina (UNESC)  Crici\u00fama Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6658-6444","authenticated-orcid":false,"given":"Alexandra I.","family":"Zugno","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences University of Southern Santa Catarina (UNESC)  Crici\u00fama Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Quevedo","sequence":"additional","affiliation":[{"name":"Translational Psychiatry Laboratory, Graduate Program in Health Sciences University of Southern Santa Catarina (UNESC)  Crici\u00fama Brazil"},{"name":"Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School University of Texas Health Science Center at Houston (UTHealth)  Houston Texas USA"},{"name":"Center of Excellence on Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School University of Texas Health Science Center at Houston (UTHealth)  Houston Texas USA"},{"name":"Center for Interventional Psychiatry, Faillace Department of Psychiatry and Behavior Sciences The University of Texas Health Science Center at Houston (UTHealth Houston)  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Dal\u2010Pizzol","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences University of Southern Santa Catarina (UNESC)  Crici\u00fama Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccx.0000142748.40422.c8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00232-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182959cfa"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90279-8"},{"key":"e_1_2_12_6_1","first-page":"31","volume-title":"Experiments in personality: Psychogenetics and psychopharmacology","author":"Broadhurst P. L.","year":"1960"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.05.005"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00055"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881112463124"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0320-2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2009.04.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0502-8"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21760"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-011-0691-9"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-022-01697-y"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.11.011"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.10.016"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2006.00209.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.08.001"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104712"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.01.002"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.05.006"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001370"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S400115"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.09.012"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881113482532"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1709304"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000191414.94461.7e"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1653450"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1553"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102755"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0708-0"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2022.136647"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90444-8"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-19-08476.2002"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.01.004"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/277093a0"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4016.1346"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.232693499"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/10.1016\/j.brainres.2020.146780"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.33.5.1218"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.09.030"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-019-00503-3"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01808-1"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.1.189"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480513"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125050"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20601"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2017.1279149"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(77)90043-4"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0622-8"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.214"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104906"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14558"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(78)90005-9"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0370-8"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9671-3"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089681"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2019.05.009"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.10.370"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12299"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2782-x"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.11.034"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.16064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T11:02:10Z","timestamp":1711018930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.16064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/ejn.16064"],"URL":"https:\/\/doi.org\/10.1111\/ejn.16064","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.16064\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.16064\/v1\/review3","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,23]]},"assertion":[{"value":"2022-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}