{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:23:14Z","timestamp":1792588994036,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T00:00:00Z","timestamp":1687564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["R01HD075777"],"award-info":[{"award-number":["R01HD075777"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cross\u2010education, a phenomenon where unilateral strength (or skill) training enhances strength (or skill) in the contralateral untrained limb, has been well studied in able\u2010bodied individuals. Cross\u2010education effect accompanies bilateral changes of corticomotor activity in the motor cortex (M1). Recent reports demonstrated greater cross\u2010education effect in stroke survivors compared to healthy individuals, however, corticomotor responses to cross\u2010education in stroke remains unclear. This study aimed to determine the effects of non\u2010paretic leg movements on corticomotor excitability (CME) and reaction time of the paretic leg in severely impaired stroke survivors. Seventeen post stroke individuals with severe leg motor impairment (Fugl\u2010Meyer lower extremity score less than 21 and absence of motor evoked potential in the paretic leg) performed three 20\u2010min motor trainings using their non\u2010paretic ankle: skill (targeted dynamic movements), strength (isometric resistance) and sham (sub\u2010threshold electrical nerve stimulation). During training, verbal instructions were given to the participants to limit their movement to the non\u2010paretic leg and this was confirmed with visual observation of the paretic leg. Transcranial magnetic stimulation measured CME of the contralateral pathways from the non\u2010lesioned M1 to the non\u2010paretic tibialis anterior (TA) muscle, ipsilateral pathways to the paretic TA and transcallosal inhibition (TCI) from the non\u2010lesioned to lesioned M1. Paretic ankle reaction time was measured using a reaction time paradigm. All outcomes were measured before, immediately post, 30\u2010min post and 60\u2010min post priming. CME of the non\u2010paretic TA increased after skill (.08\u2009\u00b1\u2009.10\u2009mV) and strength (.06\u2009\u00b1\u2009.05\u2009mV) training (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01). Ipsilateral CME of the paretic TA (.02\u2009\u00b1\u2009.01\u2009mV) and TCI (.01\u2009\u00b1\u2009.01\u2009s, ipsilateral silent period; more inhibition to the lesioned M1) increased after skill (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05) but not strength training. Reaction time of the paretic ankle improved after skill and strength training (\u2212.11\u2009\u00b1\u2009.2 and \u2212.13\u2009\u00b1\u2009.20\u2009s, respectively;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05) and was sustained at 60\u2009min. No changes were observed during the sham condition. Our findings may inform future studies for using non\u2010paretic leg movements as a priming modality, especially for those who are contraindicated to other priming paradigms (e.g., brain stimulation) or unable to perform paretic leg movements. Conclusion: Non\u2010paretic leg movements can be used as a priming modality, especially for those who are contraindicated to other priming paradigms (e.g., brain stimulation) or unable to perform paretic leg movements.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16069","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T21:45:32Z","timestamp":1687643132000},"page":"2853-2867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Non\u2010paretic leg movements can facilitate cortical drive to the paretic leg in individuals post stroke with severe motor impairment: Implications for motor priming"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7147-8026","authenticated-orcid":false,"given":"Hyosok","family":"Lim","sequence":"first","affiliation":[{"name":"Brain Plasticity Laboratory, Department of Physical Therapy University of Illinois at Chicago  Chicago Illinois USA"},{"name":"Graduate Program in Rehabilitation Sciences, College of Applied Health Sciences University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-0027","authenticated-orcid":false,"given":"Sangeetha","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Brain Plasticity Laboratory, Department of Physical Therapy University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00515.2006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.88.1.124"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00222-5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr344"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00184"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00064.2020"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.01.004"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.024463"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0545i.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110079401500205"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210100815"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00323.2018"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-015-4470-y"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178636"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000001162"},{"key":"e_1_2_12_17_1","first-page":"138","article-title":"The comparison of cross\u2010education effect in young and elderly females from unilateral training of the elbow flexors","volume":"28","author":"Ehsani F.","year":"2014","journal-title":"Medical Journal of the Islamic Republic of Iran"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.09.018"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gloepi.2019.100012"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05117-8"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.02.012"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23316"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10833196.2018.1499272"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4281532"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31820a94b8"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(95)80038-7"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1986.63.2.455"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1123\/mcj.15.2.247"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2019.01.027"},{"issue":"3","key":"e_1_2_12_30_1","first-page":"A13","article-title":"Sex differences in stroke recovery","volume":"2","author":"Lai S. 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