{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:43:11Z","timestamp":1787499791445,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002583","name":"American Hearing Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002583","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Meniere's disease (MD) is a disorder of the inner ear characterized by chronic episodes of vertigo, tinnitus, increased aural pressure, and sensorineural hearing loss. Causes of MD are unknown, but endolymphatic hydrops is a hallmark. In addition, 5%\u201315% of MD cases have been identified as familial. Whole\u2010genome sequencing studies of individuals with familial MD identified DTNA and FAM136A as candidate genes for autosomal dominant inheritance of MD. Although the exact roles of these genes in MD are unknown, FAM136A encodes a mitochondrial protein, and DTNA encodes a cytoskeletal protein involved in synapse formation and maintenance, important for maintaining the blood\u2013brain barrier. It is also associated with a particular aquaporin. We tested vestibular and auditory function in\n                    <jats:italic>dtna<\/jats:italic>\n                    and\n                    <jats:italic>fam136a<\/jats:italic>\n                    knockout (KO) mice, using RotaRod and startle reflex\u2010based clicker tests, respectively. Three\u2010factor analysis of variance (ANOVA) results indicated that sex, age, and genotype were significantly correlated with reduced mean latencies to fall (\u201clatencies\u201d) for male\n                    <jats:italic>dtna<\/jats:italic>\n                    KO mice, while only age was a significant factor for\n                    <jats:italic>fam136a<\/jats:italic>\n                    KO mice.\n                    <jats:italic>Fam136a<\/jats:italic>\n                    KO mice lost their hearing months before WTs (9\u201311\u2009months vs. 15\u201320\u2009months). In male\n                    <jats:italic>dtna<\/jats:italic>\n                    KO mice, divergence in mean latencies compared with other genotypes was first evident at 4\u00a0months of age, with older males having an even greater decrease. Our results indicate that\n                    <jats:italic>fam136a<\/jats:italic>\n                    gene mutations generate hearing problems, while\n                    <jats:italic>dtna<\/jats:italic>\n                    gene mutations produce balance deficits. Both mouse models should help to elucidate hearing loss and balance\u2010related symptoms associated with MD.\n                  <\/jats:p>","DOI":"10.1111\/ejn.16083","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T02:48:21Z","timestamp":1689648501000},"page":"2708-2723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["RotaRod and acoustic startle reflex performance of two potential mouse models for Meniere's disease"],"prefix":"10.1111","volume":"58","author":[{"given":"Vidya","family":"Babu","sequence":"first","affiliation":[{"name":"University of Illinois at Chicago College of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Bahari","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Medicine  Chicago Illinois 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